Cooperative defence operates by social modulation of biogenic amine levels in the honey bee brain

Morgane Nouvian, Souvik Mandal, Charlène Jamme, Charles Claudianos, Patrizia D’Ettorre, Judith Reinhard, Andrew B. Barron, Martin Giurfa

Research output: Contribution to journalArticle

Abstract

The defence of a society often requires that some specialized members coordinate to repel a threat at personal risk. This is especially true for honey bee guards, which defend the hive and may sacrifice their lives upon stinging. Central to this cooperative defensive response is the sting alarm pheromone, which has isoamyl acetate (IAA) as its main component. Although this defensive behaviour has been well described, the neural mechanisms triggered by IAA to coordinate stinging have long remained unknown. Here we show that IAA upregulates brain levels of serotonin and dopamine, thereby increasing the likelihood of an individual bee to attack and sting. Pharmacological enhancement of the levels of both amines induces higher defensive responsiveness, while decreasing them via antagonists decreases stinging. Our results thus uncover the neural mechanism by which an alarm pheromone recruits individuals to attack and repel a threat, and suggest that the alarm pheromone of honey bees acts on their response threshold rather than as a direct trigger.

LanguageEnglish
Article number20172653
Pages1-9
Number of pages9
JournalProceedings of the Royal Society B: Biological Sciences
Volume285
Issue number1871
DOIs
StatePublished - 31 Jan 2018

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alarm pheromones
stinging
Biogenic Amines
Honey
Bees
Pheromones
biogenic amines
honey
pheromone
bee
cooperatives
honey bees
brain
Brain
acetate
acetates
Modulation
Bites and Stings
defensive behavior
Urticaria

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Nouvian, M., Mandal, S., Jamme, C., Claudianos, C., D’Ettorre, P., Reinhard, J., ... Giurfa, M. (2018). Cooperative defence operates by social modulation of biogenic amine levels in the honey bee brain. Proceedings of the Royal Society B: Biological Sciences, 285(1871), 1-9. [20172653]. DOI: 10.1098/rspb.2017.2653
Nouvian, Morgane ; Mandal, Souvik ; Jamme, Charlène ; Claudianos, Charles ; D’Ettorre, Patrizia ; Reinhard, Judith ; Barron, Andrew B. ; Giurfa, Martin. / Cooperative defence operates by social modulation of biogenic amine levels in the honey bee brain. In: Proceedings of the Royal Society B: Biological Sciences. 2018 ; Vol. 285, No. 1871. pp. 1-9
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Nouvian, M, Mandal, S, Jamme, C, Claudianos, C, D’Ettorre, P, Reinhard, J, Barron, AB & Giurfa, M 2018, 'Cooperative defence operates by social modulation of biogenic amine levels in the honey bee brain' Proceedings of the Royal Society B: Biological Sciences, vol 285, no. 1871, 20172653, pp. 1-9. DOI: 10.1098/rspb.2017.2653

Cooperative defence operates by social modulation of biogenic amine levels in the honey bee brain. / Nouvian, Morgane; Mandal, Souvik; Jamme, Charlène; Claudianos, Charles; D’Ettorre, Patrizia; Reinhard, Judith; Barron, Andrew B.; Giurfa, Martin.

In: Proceedings of the Royal Society B: Biological Sciences, Vol. 285, No. 1871, 20172653, 31.01.2018, p. 1-9.

Research output: Contribution to journalArticle

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Nouvian M, Mandal S, Jamme C, Claudianos C, D’Ettorre P, Reinhard J et al. Cooperative defence operates by social modulation of biogenic amine levels in the honey bee brain. Proceedings of the Royal Society B: Biological Sciences. 2018 Jan 31;285(1871):1-9. 20172653. Available from, DOI: 10.1098/rspb.2017.2653