Corneal collagen cross-linking for post-lasik ectasia: an Australian study

Jessica Tong, Deepa Viswanathan, Christopher Hodge, Gerard Sutton, Colin Chan, John Males

Research output: Contribution to journalMeeting abstract


Purpose: Post laser-assisted in situ keratomileusis (LASIK) ectasia is a rare and unpredictable complication that can occur up to several years following LASIK. Corneal collagen crosslinking (CXL) has emerged as a promising technique to address this complication. Our study evaluates an Australian experience with CXL treatment for post-LASIK ectasia and its long-term efficacy.
Method: Retrospective review of post-LASIK ectasia patients referred to and treated at three corneal refractive surgery institutions in Sydney, Australia. Best spectacle-corrected visual acuity (BSCVA), simulated keratometry, higher-order aberrations (HOAs) and corneal topography indices were measured with a rotating Scheimpflug camera (Pentacam, Oculus). Comparisons between pre-operative and last postoperative outcomes (mean ± SEM) were performed using paired t-test analysis. A p-value <0.05 was considered statistically significant.
Results: Eighteen patients (23 eyes; mean age 39.3 ± 11.1 SD years) underwent epithelium-off CXL, with follow-up ranging from 6–78 months. BSCVA improved significantly by 0.18 ± 0.05 logMAR (p = 0.002). Keratometry in the steepest meridian (K2) decreased by 0.34 ± 0.29 dioptres (p = 0.3). Eighteen of 23 eyes demonstrated no keratometric deterioration at last follow-up. Of the corneal HOAs, improvements were observed in primary horizontal coma (p= 0.2) and vertical coma (p= 0.2). Of the corneal topography indices, index of height asymmetry improved significantly by 7.06 ± 3.07 (p = 0.04), indicating a shift towards corneal regularity and stabilisation. Central corneal thickness was not significantly altered (p = 0.7). There were no postoperative complications.
Conclusion: In the Australian setting, CXL is a safe and effective treatment for reversing the progression of post-LASIK ectasia, inducing corneal regularity and improving visual acuity.
Original languageEnglish
Pages (from-to)71
Number of pages1
JournalClinical and Experimental Ophthalmology
Issue numberSuppl. 1
Publication statusPublished - Nov 2016
Externally publishedYes
EventAnnual Scientific Congress of the Royal Australian and New Zealand College of Ophthalmologists (48th : 2016) - Melbourne, Australia
Duration: 19 Nov 201623 Nov 2016


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