Corneal collagen crosslinking for post-lasik ectasia: an Australian study

Jessica Y. Tong*, Deepa Viswanathan, Christopher Hodge, Gerard Sutton, Colin Chan, John J. Males

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)


    Purpose: Post laser-Assisted in situ keratomileusis (LASIK) ectasia is a rare and unpredictable complication after LASIK. Corneal collagen crosslinking (CXL) has emerged as a promising technique to address this complication. Our study evaluates the long-Term efficacy of CXLfor post-LASIK ectasia in an Australian setting.Design: Retrospective review of post-LASIK ectasia patients referred to and treated at 3 corneal refractive surgery institutions in Sydney, Australia. Methods: Eleven patients (14 eyes; mean age, 39.7 ± 12.6 years) underwent epithelium-off CXL with follow-up ranging from 12-78 months. Best spectacle-corrected visual acuity (BSCVA), simulated keratometry, corneal topography indices, and higher-order aberrations (HOAs) [mean ± standard error of the mean (SEM)] were measured with a rotating Scheimpflug camera (Pentacam, Oculus). Comparisons between baseline measurements and postoperative outcomes were performed using paired t test analysis. Results: At last follow-up, BSCVAimproved significantly by 0.2 ± 0.06 logMAR (P = 0.01), and 12 of 14 eyes showed no keratometric deterioration. Of the corneal topography indices, index of height asymmetry showed a trend toward a significant improvement (P = 0.05). There was no progression of corneal HOAs. Central corneal thickness was not significantly altered (P = 0.6). No major postoperative complications were observed. Conclusions: In the Australian setting, CXLhas proven effective at stabilizing the progression of post-LASIK ectasia, inducing corneal regularity, and improving visual acuity.

    Original languageEnglish
    Pages (from-to)228-232
    Number of pages5
    JournalAsia-Pacific Journal of Ophthalmology
    Issue number3
    Publication statusPublished - 2017


    • crosslinking
    • ectasia
    • LASIK
    • refractive surgery


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