Coronary artery disease is the major late complication of successful cadaveric renal transplantation

J. F. Mahony; R. J. Caterson; C. A. Pollock; M. Jones; D. A. Waugh; A. G R Sheil

Coronary artery disease is the major late complication of successful cadaveric renal transplantation

J. F. Mahony, R. J. Caterson, C. A. Pollock, M. Jones, D. A. Waugh, A. G R Sheil

Research output: Contribution to journal › Article › peer-review

Abstract

The mortality and morbidity due to coronary artery disease (CAD) were determined in a cohort of successful renal transplant recipients. In 133 cadaveric renal allograft recipients who survived at least 10 years (range 10.0-19.4, mean 14.0) from transplantation, 32 subsequently died. The commonest cause of death was myocardial infarction (37.5%), followed by sepsis (25%) and malignancy (16%). The age- and sex-adjusted increase in mortality rate from CAD was 6.76 times that of a normal population. Of the survivors, 23 (24%) have symptomatic (CAD), with half of these having had at least one proven myocardial infarction. As coronary atherosclerosis complicates all phases of renal failure and its treatment, an aggressive approach to controlling the known risk factors is warranted from the earliest stages of renal impairment.

Original language	English
Pages (from-to)	129-132
Number of pages	4
Journal	Clinical Transplantation
Volume	4
Issue number	3
Publication status	Published - 1990
Externally published	Yes

Keywords

complication
coronary artery disease
renal transplantation

Cite this

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title = "Coronary artery disease is the major late complication of successful cadaveric renal transplantation",

abstract = "The mortality and morbidity due to coronary artery disease (CAD) were determined in a cohort of successful renal transplant recipients. In 133 cadaveric renal allograft recipients who survived at least 10 years (range 10.0-19.4, mean 14.0) from transplantation, 32 subsequently died. The commonest cause of death was myocardial infarction (37.5%), followed by sepsis (25%) and malignancy (16%). The age- and sex-adjusted increase in mortality rate from CAD was 6.76 times that of a normal population. Of the survivors, 23 (24%) have symptomatic (CAD), with half of these having had at least one proven myocardial infarction. As coronary atherosclerosis complicates all phases of renal failure and its treatment, an aggressive approach to controlling the known risk factors is warranted from the earliest stages of renal impairment.",

keywords = "complication, coronary artery disease, renal transplantation",

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year = "1990",

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TY - JOUR

T1 - Coronary artery disease is the major late complication of successful cadaveric renal transplantation

AU - Mahony, J. F.

AU - Caterson, R. J.

AU - Pollock, C. A.

AU - Jones, M.

AU - Waugh, D. A.

AU - Sheil, A. G R

PY - 1990

Y1 - 1990

N2 - The mortality and morbidity due to coronary artery disease (CAD) were determined in a cohort of successful renal transplant recipients. In 133 cadaveric renal allograft recipients who survived at least 10 years (range 10.0-19.4, mean 14.0) from transplantation, 32 subsequently died. The commonest cause of death was myocardial infarction (37.5%), followed by sepsis (25%) and malignancy (16%). The age- and sex-adjusted increase in mortality rate from CAD was 6.76 times that of a normal population. Of the survivors, 23 (24%) have symptomatic (CAD), with half of these having had at least one proven myocardial infarction. As coronary atherosclerosis complicates all phases of renal failure and its treatment, an aggressive approach to controlling the known risk factors is warranted from the earliest stages of renal impairment.

AB - The mortality and morbidity due to coronary artery disease (CAD) were determined in a cohort of successful renal transplant recipients. In 133 cadaveric renal allograft recipients who survived at least 10 years (range 10.0-19.4, mean 14.0) from transplantation, 32 subsequently died. The commonest cause of death was myocardial infarction (37.5%), followed by sepsis (25%) and malignancy (16%). The age- and sex-adjusted increase in mortality rate from CAD was 6.76 times that of a normal population. Of the survivors, 23 (24%) have symptomatic (CAD), with half of these having had at least one proven myocardial infarction. As coronary atherosclerosis complicates all phases of renal failure and its treatment, an aggressive approach to controlling the known risk factors is warranted from the earliest stages of renal impairment.

KW - complication

KW - coronary artery disease

KW - renal transplantation

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M3 - Article

AN - SCOPUS:0025299283

SN - 0902-0063

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EP - 132

JO - Clinical Transplantation

JF - Clinical Transplantation

IS - 3

ER -

Coronary artery disease is the major late complication of successful cadaveric renal transplantation

Abstract

Keywords

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