Coronary artery disease is the major late complication of successful cadaveric renal transplantation

J. F. Mahony, R. J. Caterson, C. A. Pollock, M. Jones, D. A. Waugh, A. G R Sheil

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Abstract

The mortality and morbidity due to coronary artery disease (CAD) were determined in a cohort of successful renal transplant recipients. In 133 cadaveric renal allograft recipients who survived at least 10 years (range 10.0-19.4, mean 14.0) from transplantation, 32 subsequently died. The commonest cause of death was myocardial infarction (37.5%), followed by sepsis (25%) and malignancy (16%). The age- and sex-adjusted increase in mortality rate from CAD was 6.76 times that of a normal population. Of the survivors, 23 (24%) have symptomatic (CAD), with half of these having had at least one proven myocardial infarction. As coronary atherosclerosis complicates all phases of renal failure and its treatment, an aggressive approach to controlling the known risk factors is warranted from the earliest stages of renal impairment.

Original languageEnglish
Pages (from-to)129-132
Number of pages4
JournalClinical Transplantation
Volume4
Issue number3
Publication statusPublished - 1990
Externally publishedYes

Keywords

  • complication
  • coronary artery disease
  • renal transplantation

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    Mahony, J. F., Caterson, R. J., Pollock, C. A., Jones, M., Waugh, D. A., & Sheil, A. G. R. (1990). Coronary artery disease is the major late complication of successful cadaveric renal transplantation. Clinical Transplantation, 4(3), 129-132.