Correction

William C. Nierman, Tamara V. Feldblyum, Michael T. Laub, Ian T. Paulsen, Karen E. Nelson, Jonathan Eisen, John F. Heidelberg, M. R K Alley, Noriko Ohta, Janine R. Maddock, Isabel Potocka, William C. Nelson, Austin Newton, Craig Stephens, Nikhil D. Phadke, Bert Ely, Robert T. DeBoy, Robert J. Dodson, A. Scott Durkin, Michelle L. Gwinn & 17 others Daniel H. Haft, James F. Kolonay, John Smit, M. B. Craven, Hoda Khouri, Jyoti Shetty, Kristi Berry, Teresa Utterback, Kevin Tran, Alex Wolf, Jessica Vamathevan, Maria Ermolaeva, Owen White, Steven L. Salzberg, J. Craig Venter, Lucy Shapiro, Claire M. Fraser

Research output: Contribution to journalOther journal contribution

Abstract

The complete genome sequence of Caulobacter crescentus was determined to be 4,016,942 base pairs in a single circular chromosome encoding 3,767 genes. This organism, which grows in a dilute aquatic environment, coordinates the cell division cycle and multiple cell differentiation events. With the annotated genome sequence, a full description of the genetic network that controls bacterial differentiation, cell growth, and cell cycle progression is within reach. Two-component signal transduction proteins are known to play a significant role in cell cycle progression. Genome analysis revealed that the C. crescentus genome encodes a significantly higher number of these signaling proteins (105) than any bacterial genome sequenced thus far. Another regulatory mechanism involved in cell cycle progression is DNA methylation. The occurrence of the recognition sequence for an essential DNA methylating enzyme that is required for cell cycle regulation is severely limited and shows a bias to intergenic regions. The genome contains multiple clusters of genes encoding proteins essential for survival in a nutrient poor habitat. Included are those involved in chemotaxis, outer membrane channel function, degradation of aromatic ring compounds, and the breakdown of plant-derived carbon sources, in addition to many extracytoplasmic function sigma factors, providing the organism with the ability to respond to a wide range of environmental fluctuations. C. crescentus is, to our knowledge, the first free-living α-class proteobacterium to be sequenced and will serve as a foundation for exploring the biology of this group of bacteria, which includes the obligate endosymbiont and human pathogen Rickettsia prowazekii, the plant pathogen Agrobacterium tumefaciens, and the bovine and human pathogen Brucella abortus.

Original languageEnglish
Pages (from-to)6533
Number of pages1
JournalProceedings of the National Academy of Sciences of the United States of America
Volume98
Issue number11
DOIs
Publication statusPublished - 27 Mar 2001
Externally publishedYes

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