Correlations between integrin ανβ6 expression and clinico-pathological features in stage B and stage C rectal cancer

Seong Beom Ahn, Abidali Mohamedali, Charles Chan, Julie Fletcher, Sun Young Kwun, Candice Clarke, Owen F. Dent, Pierre H. Chapuis, Edouard Nice, Mark S. Baker

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    Abstract

    Integrin anb6 is highly expressed in a range of human cancers and frequently correlates with patient survival. This study examines correlations between ανβ6 expression and patient clinico-pathological features in Stage B and Stage C rectal cancer, including overall survival. Expression of ανβ6 was measured in 362 Stage B or C rectal cancer tissue samples at the tumour central region, invasive tumour front and adjacent non-neoplastic mucosa using immunohistochemistry. Distribution of ανβ6 was found to be significantly higher at the invasive front compared to central regions of the tumour (p<0.001) or adjacent non-neoplastic mucosa (p<0.001) suggesting anb 6 plays a role in tumour cell invasion. However, integrin ανβ6 expression was not associated with clinico-pathological features or overall survival indicating it is not an independent prognostic marker differentiating Stage B or C rectal cancer. Previous ανβ6 studies have suggested the expression of ανβ6 is involved in the earlier stages (i.e. Stages A/B) of tumour progression rather than the later stages (i.e. Stages C/D). However, our study has revealed that in rectal cancer ανβ6 expression does not increase between Stages B and C, but may occur earlier, namely before or during Stage B cancer.

    Original languageEnglish
    Article numbere97248
    Number of pages8
    JournalPLoS ONE
    Volume9
    Issue number5
    DOIs
    Publication statusPublished - May 2014

    Bibliographical note

    Copyright the Author(s) 2014. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

    A correction exists for this article and can be found in PLoS ONE, 9(8), e104724. doi: 10.1371/journal.pone.0104724.

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