TY - JOUR
T1 - Correlations between integrin ανβ6 expression and clinico-pathological features in stage B and stage C rectal cancer
AU - Ahn, Seong Beom
AU - Mohamedali, Abidali
AU - Chan, Charles
AU - Fletcher, Julie
AU - Kwun, Sun Young
AU - Clarke, Candice
AU - Dent, Owen F.
AU - Chapuis, Pierre H.
AU - Nice, Edouard
AU - Baker, Mark S.
N1 - Copyright the Author(s) 2014. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
A correction exists for this article and can be found in PLoS ONE, 9(8), e104724. doi: 10.1371/journal.pone.0104724.
PY - 2014/5
Y1 - 2014/5
N2 - Integrin anb6 is highly expressed in a range of human cancers and frequently correlates with patient survival. This study examines correlations between ανβ6 expression and patient clinico-pathological features in Stage B and Stage C rectal cancer, including overall survival. Expression of ανβ6 was measured in 362 Stage B or C rectal cancer tissue samples at the tumour central region, invasive tumour front and adjacent non-neoplastic mucosa using immunohistochemistry. Distribution of ανβ6 was found to be significantly higher at the invasive front compared to central regions of the tumour (p<0.001) or adjacent non-neoplastic mucosa (p<0.001) suggesting anb 6 plays a role in tumour cell invasion. However, integrin ανβ6 expression was not associated with clinico-pathological features or overall survival indicating it is not an independent prognostic marker differentiating Stage B or C rectal cancer. Previous ανβ6 studies have suggested the expression of ανβ6 is involved in the earlier stages (i.e. Stages A/B) of tumour progression rather than the later stages (i.e. Stages C/D). However, our study has revealed that in rectal cancer ανβ6 expression does not increase between Stages B and C, but may occur earlier, namely before or during Stage B cancer.
AB - Integrin anb6 is highly expressed in a range of human cancers and frequently correlates with patient survival. This study examines correlations between ανβ6 expression and patient clinico-pathological features in Stage B and Stage C rectal cancer, including overall survival. Expression of ανβ6 was measured in 362 Stage B or C rectal cancer tissue samples at the tumour central region, invasive tumour front and adjacent non-neoplastic mucosa using immunohistochemistry. Distribution of ανβ6 was found to be significantly higher at the invasive front compared to central regions of the tumour (p<0.001) or adjacent non-neoplastic mucosa (p<0.001) suggesting anb 6 plays a role in tumour cell invasion. However, integrin ανβ6 expression was not associated with clinico-pathological features or overall survival indicating it is not an independent prognostic marker differentiating Stage B or C rectal cancer. Previous ανβ6 studies have suggested the expression of ανβ6 is involved in the earlier stages (i.e. Stages A/B) of tumour progression rather than the later stages (i.e. Stages C/D). However, our study has revealed that in rectal cancer ανβ6 expression does not increase between Stages B and C, but may occur earlier, namely before or during Stage B cancer.
UR - http://www.scopus.com/inward/record.url?scp=84901247443&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/record.url?scp=84905394919&partnerID=8YFLogxK
UR - https://doi.org/10.1371/journal.pone.0104724
UR - http://purl.org/au-research/grants/nhmrc/1010303
U2 - 10.1371/journal.pone.0097248
DO - 10.1371/journal.pone.0097248
M3 - Article
C2 - 24821188
AN - SCOPUS:84901247443
SN - 1932-6203
VL - 9
JO - PLoS ONE
JF - PLoS ONE
IS - 5
M1 - e97248
ER -