Correlation between high expression levels of jumonji domain-containing 4 and short survival in cases of colon adenocarcinoma

Yi Jung Ho, Cheng Ping Shih, Kun Tu Yeh, Bingyang Shi, Zhiyuan Gong, Yueh Min Lin*, Jeng Wei Lu

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In this study, we investigated the expression of jumonji domain-containing 4 (JMJD4) in colon adenocarcinoma (CA) look for evidences for future studies on clinical diagnostic and prognostic value. The immunohistochemical (IHC) reactivity of JMJD4 was assessed in human tissue microarrays using monoclonal antibodies. An initial investigation revealed that the expression of JMJD4 protein was significantly higher in tumor tissue of the colon and liver than in normal tissue. Upon further investigation, we observed significant positivity of JMJD4 between 59 paired samples from CA tissue and adjacent normal tissue. JMJD4 protein expression in CA differed significantly according to the histological grade and M-class (distant metastasis). We also determined that the mRNA or protein expression of JMJD4 was significantly associated with poor survival in patients with CA. Finally, univariate and multivariate analysis revealed that JMJD4 expression could be a prognostic indicator for patients with CA and may provide a new target for the development of novel therapies for the treatment of CA.

Original languageEnglish
Pages (from-to)1442-1449
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume503
Issue number3
DOIs
Publication statusPublished - 10 Sep 2018
Externally publishedYes

Keywords

  • Colon adenocarcinoma
  • Colorectal cancer
  • Immunohistochemistry
  • JMJD4
  • Prognosis

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