Efficacy and tolerability of concurrent weekly low dose cisplatin during radiation treatment of localised muscle invasive bladder transitional cell carcinoma

A report of two sequential Phase II studies from the Trans Tasman Radiation Oncology Group

Nirdosh Kumar Gogna*, John H L Matthews, Sandra L. Turner, Heidi Mameghan, Gillian M. Duchesne, Nigel Spry, Martin P. Berry, Jacqui Keller, Lee Tripcony

*Corresponding author for this work

    Research output: Contribution to journalArticle

    47 Citations (Scopus)

    Abstract

    Background and purpose: To determine the feasibility, toxicity, and clinical effectiveness of concurrent weekly cisplatin chemotherapy in conjunction with definitive radiation in the treatment of localised muscle invasive bladder cancer. Patients and methods: In January 1997 the Trans Tasman Radiation Oncology Group embarked on a Phase II study (TROG 97.01) of weekly cisplatin (35 mg/m2 × 7 doses) plus radiation to a dose of 63 Gy over 7 weeks. Following an interim toxicity analysis, the dose intensity of cisplatin was reduced to 6 cycles and the radiation schedule changed to 64 Gy over 6.5 weeks leading to the second study (TROG 99.06). A total of 113 patients were enrolled. Results: Acute grade 3 urinary toxicity occurred in 23% of the patients. Acute grade 4 pelvic toxicity was not seen. Thirty-eight patients (33%) experienced grade 3 or 4 cisplatin related toxicities with 15 patients (12%) requiring significant dose modification. The reduced dose intensity in Study 99.06 improved tolerability. Incidence of significant late morbidity was low (6%). Seventy-nine patients (70%) achieved complete remission at the 6 month cystoscopic assessment. Local invasive recurrence was seen in 11 of the 79 patients (14%). In 18 patients (16%) isolated superficial TCC/CIS were detected (6 months and beyond).The local control rate was 45% with a functional bladder being retained in 69 of the 113 patients (61%). RFS and DSS at 5 years were 33% and 50%, respectively. Conclusion: Our two sequential Phase II studies have shown that concurrent chemoradiation using weekly cisplatin in the management of localised invasive bladder TCC is feasible and reasonably well tolerated. This approach is currently being investigated further in a randomised study.

    Original languageEnglish
    Pages (from-to)9-17
    Number of pages9
    JournalRadiotherapy and Oncology
    Volume81
    Issue number1
    DOIs
    Publication statusPublished - Oct 2006

    Bibliographical note

    A corrigendum for this article exists in Radiotherapy and Oncology, vol. 83, issue 2, p. 215. DOI: 10.1016/j.radonc.2007.03.005

    Keywords

    • bladder transitional cell carcinoma
    • chemoradiation
    • weekly cisplatin

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