TY - GEN
T1 - Cost-efficacy of skin grafting techniques using negative pressure wound therapy and tissue-engineered skin for burns
AU - Nadhif, Muhammad Hanif
AU - Utomo, Muhammad Satiro
AU - Ferian, Muhammad Farel
AU - Taufikulhakim, Farhan H.
AU - Soerojo, Nadine H. P.
AU - Nain, Muhammad Dzulkarnaen
AU - Yusuf, Prasandhya A.
AU - Susanto, Anindya P.
AU - Prasetyono, Theddeus O. H.
PY - 2021/3/23
Y1 - 2021/3/23
N2 - Burns, which generate hypertrophic scar formation, may decrease functional and aesthetical aspects of patients’ quality of life. To date, grafting treatments were not only proceeded solitarily. The technological development of burn treatments emerged with approaches, such as negative pressure wound therapy (NPWT) and tissue-engineered skin (TES). By incorporating negative pressure on the wound bed, NPWT was able to remove debris, remove exudates, maintain humidity, and improve epithelization. A latter development of wound management, TES, also showed prominent results of wound healing. Benefitting from tissue engineering approaches, TES provided the wound bed with extracellular matrix (ECM) and 3D structure to support wound healing. In some reports, NPWT was combined with TES to promote better efficacy. Unfortunately, the efficacies of NPWT, TES, or NPWT-TES hybrid as assisting approaches for skin drafting techniques are not reviewed yet, as well as the cost comparison of the three treatments. In this report, the comparison of skin grafting techniques assisted with the three treatments (NPWT, TES, or NPWT-TES hybrid) was investigated in terms of efficacy and cost. The review starts with brief technical aspects of the three treatments. Subsequently, the efficacy and cost analyses were discussed.
AB - Burns, which generate hypertrophic scar formation, may decrease functional and aesthetical aspects of patients’ quality of life. To date, grafting treatments were not only proceeded solitarily. The technological development of burn treatments emerged with approaches, such as negative pressure wound therapy (NPWT) and tissue-engineered skin (TES). By incorporating negative pressure on the wound bed, NPWT was able to remove debris, remove exudates, maintain humidity, and improve epithelization. A latter development of wound management, TES, also showed prominent results of wound healing. Benefitting from tissue engineering approaches, TES provided the wound bed with extracellular matrix (ECM) and 3D structure to support wound healing. In some reports, NPWT was combined with TES to promote better efficacy. Unfortunately, the efficacies of NPWT, TES, or NPWT-TES hybrid as assisting approaches for skin drafting techniques are not reviewed yet, as well as the cost comparison of the three treatments. In this report, the comparison of skin grafting techniques assisted with the three treatments (NPWT, TES, or NPWT-TES hybrid) was investigated in terms of efficacy and cost. The review starts with brief technical aspects of the three treatments. Subsequently, the efficacy and cost analyses were discussed.
KW - cost
KW - efficacy
KW - grafting
KW - NPWT
KW - TES
UR - http://www.scopus.com/inward/record.url?scp=85103487191&partnerID=8YFLogxK
U2 - 10.1063/5.0047187
DO - 10.1063/5.0047187
M3 - Conference proceeding contribution
T3 - AIP Conference Proceedings
SP - 050008-1-050008-8
BT - The 5th Biomedical Engineering’s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
A2 - Lischer, Kenny
A2 - Supriadi, Sugeng
A2 - Rahman, Siti Fauziyah
A2 - Whulanza, Yudan
PB - AIP Publishing
CY - Depok, Indonesia
T2 - 5th International Symposium of Biomedical Engineering (ISBE) 2020
Y2 - 28 July 2020 through 29 July 2020
ER -