Cost-utility analysis of medication review with follow-up for cardiovascular outcomes: A microsimulation model

Antonio Ahumada-Canale, Constanza Vargas, Francisco Martinez-Mardones, José Cristian Plaza-Plaza, Shalom Benrimoj, Victoria Garcia-Cardenas

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background: Cardiovascular diseases are the leading cause of death. Pharmacist-led medication review with follow-up might be cost-effective preventing cardiovascular diseases.

Objective: To undertake a cost–utility analysis of the addition of pharmacist-led medication review with follow-up to usual care compared to usual care alone for cardiovascular outpatients.

Materials and methods: A state-transition microsimulation model was built to project outcomes over a lifetime time horizon. Inputs from a cluster randomized controlled trial conducted in primary health care centers in Chile with full-time pharmacists were used. Probabilities were estimated using patient-level data. Utilities and costs associated with each health state were obtained from the literature, whereas the intervention costs were retrieved from the trial. The public third-party payer perspective was used. Uncertainty was evaluated through one-way and probabilistic sensitivity analyses.

Results: For the base case analysis, an incremental cost-effectiveness ratio of $963 per quality-adjusted life-year was observed which was considered cost-effective. The results were robust to sensitivity analyses and were driven by decreased cardiovascular events resulting in lower mortality.

Conclusions: Medication review with follow-up was deemed a cost-effective addition to usual care with low uncertainty.
Original languageEnglish
Pages (from-to)1406-1414
Number of pages9
JournalHealth Policy
Issue number11
Early online date16 Sept 2021
Publication statusPublished - Nov 2021


  • Aged
  • Cardiovascular system
  • Cost-effectiveness
  • Drug Monitoring
  • Economics
  • Pharmacy


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