Cottoquinazoline A and cotteslosins A and B, metabolites from an Australian marine-derived strain of Aspergillus versicolor

Leith J. Fremlin, Andrew M. Piggott, Ernest Lacey, Robert J. Capon

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

An Australian marine-derived isolate of Aspergillus versicolor (MST-MF495) yielded the known fungal metabolites sterigmatocystin, violaceol I, violaceol II, diorcinol, (-)-cyclopenol, and viridicatol, along with a new alkaloid, cottoquinazoline A (1), and two new cyclopentapeptides, cotteslosins A (2) and B (3). Structures for 1-3 and the known compounds were determined by spectroscopic analysis. The absolute configurations of 1-3 were addressed by chemical degradation and application of the C3 Marfey's method. The use of "cellophane raft" high-nutrient media as a device for up-regulating secondary metabolite diversity in marine-derived fungi is discussed. The antibacterial properties displayed by A. versicolor (MST-MF495) were attributed to the phenols violaceol I, violaceol II, and diorcinol, while cotteslosins 2 and 3 were identified as weak cytotoxic agents.

Original languageEnglish
Pages (from-to)666-670
Number of pages5
JournalJournal of Natural Products
Volume72
Issue number4
DOIs
Publication statusPublished - 24 Apr 2009
Externally publishedYes

Fingerprint Dive into the research topics of 'Cottoquinazoline A and cotteslosins A and B, metabolites from an Australian marine-derived strain of Aspergillus versicolor'. Together they form a unique fingerprint.

Cite this