Abstract
Blockade of cell cycle re-entry in quiescent cancer cells is a strategy to prevent cancer progression and recurrence. We investigated the action and mode of action of CPF mixture (Coptis chinensis, Pinellia ternata and Fructus trichosanthis) in impeding a proliferative switch in quiescent lung cancer cells. The results indicated that CPF impeded cell cycle re-entry in quiescent lung cancer cells by reduction of FACT and c-MYC mRNA and protein levels, with concomitant decrease in H3K4 tri-methylation and RNA polymerase II occupancy at FACT and c-MYC promoter regions. Animals implanted with quiescent cancer cells that had been exposed to CPF had reduced tumour volume/weight. Thus, CPF suppresses proliferative switching through transcriptional suppression of FACT and the c-MYC, providing a new insight into therapeutic target and intervention method in impeding cancer recurrence.
Original language | English |
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Pages (from-to) | 2229-2239 |
Number of pages | 11 |
Journal | Journal of Cellular and Molecular Medicine |
Volume | 24 |
Issue number | 3 |
Early online date | 20 Jan 2020 |
DOIs | |
Publication status | Published - Feb 2020 |
Externally published | Yes |
Bibliographical note
Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.Keywords
- C-MYC
- G0 cell cycle re-entry
- lung cancer
- structure-specific recognition protein 1
- suppressor of Ty homolog-16
- c-MYC
- G cell cycle re-entry
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Identifying the chemical components of plants with the ability of impeding cancer cell proliferation for treatment
Hnit, S. S. T., Dong, Q., Xie, C. & Yao, M.
Project: Research