CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC

Ling  Bi; Chanlu Xie; Lijing Jiao; Shenyi  jin; Su Su Thae Hnit; Yao Mu; Yilun Wang; Qian  Wang; Guangbo Ge; Yaqiao Wang; Xiaodong Zhao; Xinglong Shi; Yani Kang; Paul De Souza; Tao Liu; Jia Zhou; Ling Xu; Qihan Dong

doi:10.1111/jcmm.14897

CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC

Ling Bi, Chanlu Xie, Lijing Jiao, Shenyi jin, Su Su Thae Hnit, Yao Mu, Yilun Wang, Qian Wang, Guangbo Ge, Yaqiao Wang, Xiaodong Zhao, Xinglong Shi, Yani Kang, Paul De Souza, Tao Liu, Jia Zhou, Ling Xu^*, Qihan Dong^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Blockade of cell cycle re-entry in quiescent cancer cells is a strategy to prevent cancer progression and recurrence. We investigated the action and mode of action of CPF mixture (Coptis chinensis, Pinellia ternata and Fructus trichosanthis) in impeding a proliferative switch in quiescent lung cancer cells. The results indicated that CPF impeded cell cycle re-entry in quiescent lung cancer cells by reduction of FACT and c-MYC mRNA and protein levels, with concomitant decrease in H3K4 tri-methylation and RNA polymerase II occupancy at FACT and c-MYC promoter regions. Animals implanted with quiescent cancer cells that had been exposed to CPF had reduced tumour volume/weight. Thus, CPF suppresses proliferative switching through transcriptional suppression of FACT and the c-MYC, providing a new insight into therapeutic target and intervention method in impeding cancer recurrence.

Original language	English
Pages (from-to)	2229-2239
Number of pages	11
Journal	Journal of Cellular and Molecular Medicine
Volume	24
Issue number	3
Early online date	20 Jan 2020
DOIs	https://doi.org/10.1111/jcmm.14897
Publication status	Published - Feb 2020
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

C-MYC
G0 cell cycle re-entry
lung cancer
structure-specific recognition protein 1
suppressor of Ty homolog-16
c-MYC
G cell cycle re-entry

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10.1111/jcmm.14897

Publisher version (open access)Final published version, 1.09 MBLicence: CC BY

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Bi, L., Xie, C., Jiao, L., jin, S., Hnit, S. S. T., Mu, Y., Wang, Y., Wang, Q., Ge, G., Wang, Y., Zhao, X., Shi, X., Kang, Y., De Souza, P., Liu, T., Zhou, J., Xu, L., & Dong, Q. (2020). CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC. Journal of Cellular and Molecular Medicine, 24(3), 2229-2239. https://doi.org/10.1111/jcmm.14897

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title = "CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC",

abstract = "Blockade of cell cycle re-entry in quiescent cancer cells is a strategy to prevent cancer progression and recurrence. We investigated the action and mode of action of CPF mixture (Coptis chinensis, Pinellia ternata and Fructus trichosanthis) in impeding a proliferative switch in quiescent lung cancer cells. The results indicated that CPF impeded cell cycle re-entry in quiescent lung cancer cells by reduction of FACT and c-MYC mRNA and protein levels, with concomitant decrease in H3K4 tri-methylation and RNA polymerase II occupancy at FACT and c-MYC promoter regions. Animals implanted with quiescent cancer cells that had been exposed to CPF had reduced tumour volume/weight. Thus, CPF suppresses proliferative switching through transcriptional suppression of FACT and the c-MYC, providing a new insight into therapeutic target and intervention method in impeding cancer recurrence.",

keywords = "C-MYC, G0 cell cycle re-entry, lung cancer, structure-specific recognition protein 1, suppressor of Ty homolog-16, c-MYC, G cell cycle re-entry",

author = "Ling Bi and Chanlu Xie and Lijing Jiao and Shenyi jin and Hnit, \{Su Su Thae\} and Yao Mu and Yilun Wang and Qian Wang and Guangbo Ge and Yaqiao Wang and Xiaodong Zhao and Xinglong Shi and Yani Kang and \{De Souza\}, Paul and Tao Liu and Jia Zhou and Ling Xu and Qihan Dong",

note = "Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher. ",

year = "2020",

month = feb,

doi = "10.1111/jcmm.14897",

language = "English",

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Bi, L, Xie, C, Jiao, L, jin, S, Hnit, SST, Mu, Y, Wang, Y, Wang, Q, Ge, G, Wang, Y, Zhao, X, Shi, X, Kang, Y, De Souza, P, Liu, T, Zhou, J, Xu, L & Dong, Q 2020, 'CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC', Journal of Cellular and Molecular Medicine, vol. 24, no. 3, pp. 2229-2239. https://doi.org/10.1111/jcmm.14897

TY - JOUR

T1 - CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC

AU - Bi, Ling

AU - Xie, Chanlu

AU - Jiao, Lijing

AU - jin, Shenyi

AU - Hnit, Su Su Thae

AU - Mu, Yao

AU - Wang, Yilun

AU - Wang, Qian

AU - Ge, Guangbo

AU - Wang, Yaqiao

AU - Zhao, Xiaodong

AU - Shi, Xinglong

AU - Kang, Yani

AU - De Souza, Paul

AU - Liu, Tao

AU - Zhou, Jia

AU - Xu, Ling

AU - Dong, Qihan

N1 - Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2020/2

Y1 - 2020/2

N2 - Blockade of cell cycle re-entry in quiescent cancer cells is a strategy to prevent cancer progression and recurrence. We investigated the action and mode of action of CPF mixture (Coptis chinensis, Pinellia ternata and Fructus trichosanthis) in impeding a proliferative switch in quiescent lung cancer cells. The results indicated that CPF impeded cell cycle re-entry in quiescent lung cancer cells by reduction of FACT and c-MYC mRNA and protein levels, with concomitant decrease in H3K4 tri-methylation and RNA polymerase II occupancy at FACT and c-MYC promoter regions. Animals implanted with quiescent cancer cells that had been exposed to CPF had reduced tumour volume/weight. Thus, CPF suppresses proliferative switching through transcriptional suppression of FACT and the c-MYC, providing a new insight into therapeutic target and intervention method in impeding cancer recurrence.

AB - Blockade of cell cycle re-entry in quiescent cancer cells is a strategy to prevent cancer progression and recurrence. We investigated the action and mode of action of CPF mixture (Coptis chinensis, Pinellia ternata and Fructus trichosanthis) in impeding a proliferative switch in quiescent lung cancer cells. The results indicated that CPF impeded cell cycle re-entry in quiescent lung cancer cells by reduction of FACT and c-MYC mRNA and protein levels, with concomitant decrease in H3K4 tri-methylation and RNA polymerase II occupancy at FACT and c-MYC promoter regions. Animals implanted with quiescent cancer cells that had been exposed to CPF had reduced tumour volume/weight. Thus, CPF suppresses proliferative switching through transcriptional suppression of FACT and the c-MYC, providing a new insight into therapeutic target and intervention method in impeding cancer recurrence.

KW - C-MYC

KW - G0 cell cycle re-entry

KW - lung cancer

KW - structure-specific recognition protein 1

KW - suppressor of Ty homolog-16

KW - c-MYC

KW - G cell cycle re-entry

UR - https://www.scopus.com/pages/publications/85078654443

U2 - 10.1111/jcmm.14897

DO - 10.1111/jcmm.14897

M3 - Article

C2 - 31960591

SN - 1582-1838

VL - 24

SP - 2229

EP - 2239

JO - Journal of Cellular and Molecular Medicine

JF - Journal of Cellular and Molecular Medicine

IS - 3

ER -

CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC

Abstract

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Identifying the chemical components of plants with the ability of impeding cancer cell proliferation for treatment

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CPF impedes cell cycle re-entry of quiescent lung cancer cells through transcriptional suppression of FACT and c-MYC

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

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Identifying the chemical components of plants with the ability of impeding cancer cell proliferation for treatment

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