CRAFT: Multimodality confocal skin imaging for early cancer diagnosis

Tong Peng, Hao Xie, Yichen Ding, Weichao Wang, Zhiming Li, Dayong Jin, Yuanhe Tang, Qiushi Ren, Peng Xi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Although histological analysis serves as a gold standard to cancer diagnosis, its application on skin cancer detection is largely prohibited due to its invasive nature. To obtain both the structural and pathological information in situ, a Confocal Reflectance/Auto-Fluorescence Tomography (CRAFT) system was established to examine the skin sites in vivo with both reflectance and autofluorescence modes simultaneously. Nude mice skin with cancerous sites and normal skin sites were imaged and compared with the system. The cellular density and reflective intensity in cancerous sites reflects the structural change of the tissue. With the decay coefficient analysis, the corresponding NAD(P)H decay index for cancerous sites is 1.65-fold that of normal sites, leading to a 97.8% of sensitivity and specificity for early cancer diagnosis. The results are verified by the followed histological analysis. Therefore, CRAFT may provide a novel method for the in vivo, non-invasive diagnosis of early cancer.

Original languageEnglish
Pages (from-to)469-476
Number of pages8
JournalJournal of Biophotonics
Issue number5-6
Publication statusPublished - May 2012


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