Cranial sutures: a multidisciplinary review

Antonio Di Ieva*, Emiliano Bruner, Jennilee Davidson, Patrizia Pisano, Thomas Haider, Scellig S. Stone, Michael D. Cusimano, Manfred Tschabitscher, Fabio Grizzi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

38 Citations (Scopus)


Introduction: Progress in cranial suture research is shaping our current understanding of the topic; however, emphasis has been placed on individual contributing components rather than the cranial sutural system as a whole. Improving our holistic view helps further guide clinicians who treat cranial sutural abnormalities as well as researchers who study them. Materials and methods: Information from anatomy, anthropology, surgery, and computed modeling was integrated to provide a perspective to interpret suture formation and variability within the cranial functional and structural system. Results: Evidence from experimental settings, simulations, and evolution suggest a multifactorial morphogenetic process associated with functions and morphology of the sutures. Despite molecular influences, the biomechanical cranial environment has a main role in both the ontogenetic and phylogenetic suture dynamics. Conclusions: Furthering our holistic understanding of the intricate cranial sutural system promises to expand our knowledge and enhance our ability to treat associated anomalies.

Original languageEnglish
Pages (from-to)893-905
Number of pages13
JournalChild's Nervous System
Issue number6
Publication statusPublished - Jun 2013
Externally publishedYes


  • Braincase
  • Cranial anatomy
  • Craniosynostosis
  • Fractal geometry
  • Functional craniology
  • Sutures


Dive into the research topics of 'Cranial sutures: a multidisciplinary review'. Together they form a unique fingerprint.

Cite this