Crellasterones A and B: A-norsterol derivatives from the new caledonian sponge crella incrustans

Kavita Ragini; Andrew M. Piggott; Peter Karuso

doi:10.3390/md15060177

Crellasterones A and B: A-norsterol derivatives from the new caledonian sponge crella incrustans

Kavita Ragini, Andrew M. Piggott, Peter Karuso^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

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Abstract

Two new steroids, crellasterones A (1) and B (2), together with the previously reported compound chalinasterol (3) and several nucleosides (4-7), were isolated from the sponge Crella incrustans, collected in New Caledonia. The structures of the new compounds were established by extensive NMR and mass spectroscopic analysis and revealed unprecedented marine natural products with a ring-contracted A-norsterone nucleus and 2-hydroxycyclopentenone chromophore. The absolute configurations were derived from electronic circular dichroism (ECD) measurements in conjunction with high-level density functional theory (DFT) calculations.

Original language	English
Article number	177
Pages (from-to)	1-10
Number of pages	10
Journal	Marine Drugs
Volume	15
Issue number	6
DOIs	https://doi.org/10.3390/md15060177
Publication status	Published - 15 Jun 2017

Bibliographical note

Copyright the Author(s) 2017. Licensee MDPI, Basel, Switzerland. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Crella
Crellasterone
DFT
Marine natural products
Sponge
Steroid

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10.3390/md15060177

Publisher version (open access)Final published version, 1.09 MBLicence: CC BY

Cite this

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Crellasterones A and B: A-norsterol derivatives from the new caledonian sponge crella incrustans

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