Crellasterones A and B

A-norsterol derivatives from the new caledonian sponge crella incrustans

Kavita Ragini, Andrew M. Piggott, Peter Karuso*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)
11 Downloads (Pure)

Abstract

Two new steroids, crellasterones A (1) and B (2), together with the previously reported compound chalinasterol (3) and several nucleosides (4-7), were isolated from the sponge Crella incrustans, collected in New Caledonia. The structures of the new compounds were established by extensive NMR and mass spectroscopic analysis and revealed unprecedented marine natural products with a ring-contracted A-norsterone nucleus and 2-hydroxycyclopentenone chromophore. The absolute configurations were derived from electronic circular dichroism (ECD) measurements in conjunction with high-level density functional theory (DFT) calculations.

Original languageEnglish
Article number177
Pages (from-to)1-10
Number of pages10
JournalMarine Drugs
Volume15
Issue number6
DOIs
Publication statusPublished - 15 Jun 2017

Bibliographical note

Copyright the Author(s) 2017. Licensee MDPI, Basel, Switzerland. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Crella
  • Crellasterone
  • DFT
  • Marine natural products
  • Sponge
  • Steroid

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