TY - JOUR
T1 - Critical particle size for fractionation by deterministic lateral displacement
AU - Inglis, David W.
AU - Davis, John A.
AU - Austin, Robert H.
AU - Sturm, James C.
PY - 2006
Y1 - 2006
N2 - The fractionation of small particles in a liquid based on their size in a micropost array by deterministic lateral displacement was recently demonstrated with unprecedented resolution (L. R. Huang, E. C. Cox, R. H. Austin and J. C. Sturm, Science, 2004, 304, 987-990, ref. 1). In this paper, we present a model of how the critical particle size for fractionation depends on the micropost geometry, depending specifically on the gap between posts, the offset of posts in one row with respect to another, and whether the fluid is driven by hydrodynamics or by electroosmosis. In general the critical particle diameter is much smaller than the gap, which prevents clogging. The model is supported by data with particles from 2.3 to 22 μm.
AB - The fractionation of small particles in a liquid based on their size in a micropost array by deterministic lateral displacement was recently demonstrated with unprecedented resolution (L. R. Huang, E. C. Cox, R. H. Austin and J. C. Sturm, Science, 2004, 304, 987-990, ref. 1). In this paper, we present a model of how the critical particle size for fractionation depends on the micropost geometry, depending specifically on the gap between posts, the offset of posts in one row with respect to another, and whether the fluid is driven by hydrodynamics or by electroosmosis. In general the critical particle diameter is much smaller than the gap, which prevents clogging. The model is supported by data with particles from 2.3 to 22 μm.
UR - http://www.scopus.com/inward/record.url?scp=33745727445&partnerID=8YFLogxK
U2 - 10.1039/b515371a
DO - 10.1039/b515371a
M3 - Article
C2 - 16652181
AN - SCOPUS:33745727445
VL - 6
SP - 655
EP - 658
JO - Lab on a Chip - Miniaturisation for Chemistry and Biology
JF - Lab on a Chip - Miniaturisation for Chemistry and Biology
SN - 1473-0197
IS - 5
ER -