TY - JOUR
T1 - Critically Ill elderly adults with infection
T2 - analysis of the extended prevalence of infection in intensive care study
AU - Dimopoulos, George
AU - Koulenti, Despoina
AU - Blot, Stijn
AU - Sakr, Yasser
AU - Anzueto, Antonio
AU - Spies, Claudia
AU - Violán, Jordi Solé
AU - Kett, Daniel
AU - Armaganidis, Apostolos
AU - Martin, Claude
AU - Vincent, Jean Louis
AU - Extended Prevalence of Infection in Intensive Care Study Investigators
A2 - Margarit, A.
A2 - Valentini, R.
A2 - Zazu, A. J.
A2 - Bevilacqua, C.
A2 - Curone, M.
A2 - Rabuffetti, R.
A2 - Comignani, P.
A2 - Torres Boden, M.
A2 - Chertcoff, F.
A2 - Cardonatti, G.
A2 - Adén, F.
A2 - Marcos, L.
A2 - Dónofrio, M.
A2 - Fernández, R.
A2 - Lamberghini, R.
A2 - Balasini, S.
A2 - Teves, J.
A2 - Las Heras, M.
A2 - Sinner, J.
A2 - Ceraso, D.
A2 - Curcio, D.
A2 - Aguilar, L.
A2 - Weller, C.
A2 - Cardonnet, L.
A2 - Santa Cruz, R.
A2 - Manrique, E.
A2 - Bernardez, D.
A2 - Iolster, T.
A2 - Chiappero, G.
A2 - Ramos, P.
A2 - Vergara, J.
A2 - Moine, I.
A2 - Ilutovich, S.
A2 - Jannello, G.
A2 - Waschbusch, M.
A2 - Rios Picaza, G.
A2 - Raimondi, A.
A2 - Miriam, M.
A2 - Carlos, L.
A2 - Caridi, M.
A2 - Leong, T.
A2 - Orford, N.
A2 - Reece, G.
A2 - Ernest, D.
A2 - Hawker, F.
A2 - Tan, J.
A2 - Giannellis, C.
A2 - Ihle, B.
A2 - Bersten, A.
A2 - McInness, J.
A2 - Tallott, M.
A2 - McFadyen, B.
A2 - Vibert, J.
A2 - Parr, M.
PY - 2013/12/1
Y1 - 2013/12/1
N2 - Objectives: To determine the effect of age on patterns of infection and on outcomes in individuals with infection. Design: Analysis of data from an international, observational, point-prevalence study: Extended Prevalence of Infection in Intensive Care (EPIC II). Setting: Intensive care units (ICUs; N = 1,265) in 75 countries. Participants: All adults present in a participating ICU on May 8, 2007. Individuals with an infection were included and classified according to age (18-44, 45-64, 65-74, 75-84, ≥85). Measurements: Demographic, physiological, bacteriological, and therapeutic data were collected on the day of the study. Outcome data were collected until hospital discharge or for 60 days. Results: Of the 13,796 adults enrolled in EPIC II, 7,087 (51.4%) had an infection. Of these, 330 (4.7%) were aged 85 and older, 1,405 (19.8%) were 75 to 84, 1,713 (24.2%) were 65 to 74, 2,358 (33.3%) were 45 to 64, and 1,281 (18.1%) were 18 to 44. Severity of illness did not differ between groups. Those aged 85 and older had fewer bloodstream infections than those younger than 75, fewer central nervous system infections than those who were younger than 65, and more abdominal infections than those who were younger than 45. A microbiological diagnosis was established less frequently in participants aged 85 and older than in younger participants. Gram-negative microorganisms were more frequently isolated in those aged 85 and older than in other groups. ICU and hospital mortality were significantly higher in participants aged 85 and older than in those who were younger than 65. Conclusion: A large proportion of individuals in the ICU with infection are aged 65 and older. Patterns of infection, including site and type of microorganism, vary according to age. Being aged 85 and older was an independent risk factor for mortality in individuals in the ICU with infection.
AB - Objectives: To determine the effect of age on patterns of infection and on outcomes in individuals with infection. Design: Analysis of data from an international, observational, point-prevalence study: Extended Prevalence of Infection in Intensive Care (EPIC II). Setting: Intensive care units (ICUs; N = 1,265) in 75 countries. Participants: All adults present in a participating ICU on May 8, 2007. Individuals with an infection were included and classified according to age (18-44, 45-64, 65-74, 75-84, ≥85). Measurements: Demographic, physiological, bacteriological, and therapeutic data were collected on the day of the study. Outcome data were collected until hospital discharge or for 60 days. Results: Of the 13,796 adults enrolled in EPIC II, 7,087 (51.4%) had an infection. Of these, 330 (4.7%) were aged 85 and older, 1,405 (19.8%) were 75 to 84, 1,713 (24.2%) were 65 to 74, 2,358 (33.3%) were 45 to 64, and 1,281 (18.1%) were 18 to 44. Severity of illness did not differ between groups. Those aged 85 and older had fewer bloodstream infections than those younger than 75, fewer central nervous system infections than those who were younger than 65, and more abdominal infections than those who were younger than 45. A microbiological diagnosis was established less frequently in participants aged 85 and older than in younger participants. Gram-negative microorganisms were more frequently isolated in those aged 85 and older than in other groups. ICU and hospital mortality were significantly higher in participants aged 85 and older than in those who were younger than 65. Conclusion: A large proportion of individuals in the ICU with infection are aged 65 and older. Patterns of infection, including site and type of microorganism, vary according to age. Being aged 85 and older was an independent risk factor for mortality in individuals in the ICU with infection.
KW - age
KW - critically ill
KW - infections
UR - http://www.scopus.com/inward/record.url?scp=84890510161&partnerID=8YFLogxK
U2 - 10.1111/jgs.12544
DO - 10.1111/jgs.12544
M3 - Article
C2 - 24479140
AN - SCOPUS:84890510161
SN - 0002-8614
VL - 61
SP - 2065
EP - 2071
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
IS - 12
ER -