Crohn's disease associated strictures

Webber Pak Wo Chan*, Fadi Mourad, Rupert W. L. Leong

*Corresponding author for this work

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Crohn's disease (CD) is a chronic relapsing and remitting disease that can affect any segments of the gastrointestinal tract. More than 50% of patients with CD develop stricturing or penetrating complications within the first 10 years after diagnosis. Strictures can lead to intestinal obstruction, which is a common indication for surgery. Despite significant advances in the understanding of the pathogenesis of intestinal fibrostenosis, imaging and therapeutic armamentarium of CD, the risk of intestinal surgery remained significantly high. Endoscopic balloon dilation is a promising first-line alternative to surgery as it is less invasive and could preserve intestinal length. In this review, we will evaluate the literature on the mechanism of intestinal fibrosis, emerging imaging techniques, and management strategies for CD associated strictures.

Original languageEnglish
Pages (from-to)998-1008
Number of pages11
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume33
Issue number5
DOIs
Publication statusPublished - 1 May 2018
Externally publishedYes

Keywords

  • Crohn's disease
  • endoscopic balloon dilation
  • resection
  • stricture
  • strictureplasty

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