Crooke's cell tumors of the pituitary

Antonio Di Ieva*, Jennilee M. Davidson, Luis V. Syro, Fabio Rotondo, Julian F. Montoya, Eva Horvath, Michael D. Cusimano, Kalman Kovacs

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

40 Citations (Scopus)


Crooke's cell adenomas are a rare type of pituitary neoplasm. They produce adrenocorticotropic hormone causing Cushing's disease or may be endocrinologically silent. These tumors are usually invasive, may exhibit aggressive clinical behavior, and often recur with a low success of cure after reoperation and/or radiotherapy. Due to their rarity, they present great difficulties in assessing prognosis, treatment, and clinical management. Neurosurgeons and physicians dealing with pituitary adenomas diagnosed as Crooke's cell adenomas have to be aware of their potential clinical aggressiveness to plan strict follow-up of patients and eventual multimodality treatment. We review here the published cases of Crooke's cell tumors, as well as the clinical and histopathological characteristics of these unusual neoplasms.

Original languageEnglish
Pages (from-to)616-622
Number of pages7
Issue number5
Publication statusPublished - 21 May 2015
Externally publishedYes


  • Adrenocorticotropic hormone producing pituitary tumor
  • Aggressive pituitary adenoma
  • Crooke's cell
  • Hyalinization
  • Pituitary adenoma
  • Pituitary carcinoma


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