Cross-modal plasticity in higher-order auditory cortex of congenitally deaf cats does not limit auditory responsiveness to cochlear implants

Rüdiger Land*, Peter Baumhoff, Jochen Tillein, Stephen G. Lomber, Peter Hubka, Andrej Kral

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)
4 Downloads (Pure)

Abstract

Congenital sensory deprivation can lead to reorganization of the deprived cortical regions by another sensory system. Such cross-modal reorganization may either compete with or complement the “original” inputs to the deprived area after sensory restoration and can thus be either adverse or beneficial for sensory restoration. In congenital deafness, a previous inactivation study documented that supranormal visual behavior was mediated by higher-order auditory fields in congenitally deaf cats (CDCs). However, both the auditory responsiveness of “deaf” higherorder fields and interactions between the reorganized and the original sensory input remain unknown. Here, we studied a higher-order auditory field responsible for the supranormal visual function in CDCs, the auditory dorsal zone (DZ). Hearing cats and visual cortical areas served as a control. Using mapping with microelectrode arrays, we demonstrate spatially scattered visual (cross-modal) responsiveness in the DZ, but show that this did not interfere substantially with robust auditory responsiveness elicited through cochlear implants. Visually responsive and auditory-responsive neurons in the deaf auditory cortex formed two distinct populations that did not show bimodal interactions. Therefore, cross-modal plasticity in the deaf higher-order auditory cortex had limited effects on auditory inputs. The moderate number of scattered cross-modally responsive neurons could be the consequence of exuberant connections formed during development that were not pruned postnatally in deaf cats. Although juvenile brain circuits are modified extensively by experience, the main driving input to the cross-modally (visually) reorganized higher-order auditory cortex remained auditory in congenital deafness.

Original languageEnglish
Pages (from-to)6175-6185
Number of pages11
JournalJournal of Neuroscience
Volume36
Issue number23
DOIs
Publication statusPublished - 8 Jun 2016
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2016. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Cochlear implant
  • Cross-modal plasticity
  • Deaf white cat
  • Deafness
  • Deprivation
  • Development

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