Cross-sectional associations between inflammation, sickness behaviour, health anxiety and self-rated health in a Swedish primary care population

Karin Lodin, Mats Lekander, Predrag Petrovic, Gustav Nilsonne, Erik Hedman-Lagerlöf, Anna Andreasson*

*Corresponding author for this work

    Research output: Contribution to journalLetter

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    Abstract

    This study investigated associations between inflammatory markers, sickness behaviour, health anxiety and self-rated health in 311 consecutive primary care patients. Poor self-rated health was associated with high sickness behaviour (ρ = 0.28, P < 0.001; ρ = 0.42, P = 0.003) and high health anxiety (ρ = 0.31, P < 0.001; ρ = –0.32, P = 0.003). High levels of interleukin 6 were associated with poor self-rated health in men (ρ = 0.26, P = 0.009). Low levels of interleukin-6 were associated with poor self-rated health in women (ρ = –0.15, P = 0.04), but this association was non-significant when adjusted for health anxiety (ρ = –0.08, P = 0.31). These results are consistent with the theory that interoceptive processes draw on both inflammatory mediators and the state of sickness behaviour in inferring health state.

    Original languageEnglish
    Pages (from-to)1-6
    Number of pages6
    JournalEuropean Journal of Inflammation
    Volume17
    DOIs
    Publication statusPublished - 1 Jan 2019

    Bibliographical note

    Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

    Keywords

    • cytokine
    • health anxiety
    • inflammation
    • self-rated health
    • sickness behaviour

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