Crosslinked-polyvinyl alcohol-carboxymethyl cellulose/ZnO nanocomposite fibrous mats containing erythromycin (PVA-CMC/ZnO-EM): Fabrication, characterization and in-vitro release and anti-bacterial properties

Behzad Darbasizadeh, Yousef Fatahi, Bahareh Feyzi-barnaji, Mahshid Arabi, Hamidreza Motasadizadeh, Hassan Farhadnejad*, Fatemeh Moraffah, Navid Rabiee

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Recently, nanocomposite nanofibers have been extensively used for biomedical applications. It is expected that simultaneous incorporation of antibiotic drugs and ZnO nanoparticles into nanofiber resulted in providing the synergistic anti-bacterial effect. The main aim of the present study is to fabricate polyvinyl alcohol (PVA)/carboxymethyl cellulose (CMC)-ZnO nanocomposite fibrous mats containing erythromycin (EM) drug and crosslink them using 2% glutaraldehyde vapor and 3% AlCl3 alcoholic solution. The fabricated nanofibers characterized via TGA, FTIR, TEM, and SEM, indicating that the addition of ZnO nanoparticles and EM molecules into the fabricated nanofibers resulted in changing their average diameter. Their anti-bacterial activity was studied against S. aureus and E. coli and found that PVA-CMC/ZnO-EM nanofibers show excellent antimicrobial activity. In-vitro release profile showed that EM release from PVA-CMC/ZnO-EM nanofibers was slowly increased. Sustained drug release profile and excellent anti-bacterial activity of PVA-CMC/ZnO-EM nanofiber indicated that it was an ideal biomaterial for wound dressings.

Original languageEnglish
Pages (from-to)1137-1146
Number of pages10
JournalInternational Journal of Biological Macromolecules
Volume141
DOIs
Publication statusPublished - 1 Dec 2019
Externally publishedYes

Keywords

  • Antibiotics
  • Electrospinning
  • Nanofiber
  • ZnO nanoparticles

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