Cryobiopsy with radial-endobronchial ultrasound (Cryo-Radial) has comparable diagnostic yield with higher safety in comparison with computed tomography-guided transthoracic biopsy for peripheral pulmonary lesions: an exploratory randomised study

Samantha Herath*, Conroy Wong, Paul Dawkins, Andrew Veale, Elaine Yap, Jonathan Williamson, Irene Low, Hema Mahajan, Tania Prvan, Stuart Barnard, Stewart Hawkins, Dan Cookson, Tushar Singh, Alvin Ing

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Computed tomography-guided transthoracic biopsy (CT-TTB) is the ‘gold standard’ biopsy for lung nodules. Radial-endobronchial ultrasound (R-EBUS) bronchoscopy is another recommended biopsy but carries a lower diagnostic yield. Addition of cryobiopsy with R-EBUS (Cryo-Radial) has shown promising results. There are no studies comparing CT-TTB with Cryo-Radial biopsy. Aim: The co-primary aims were the diagnostic yeild and safety. The secondary aim: ability to test epidermal growth factor receptor (EGFR). Methods: A randomised controlled, multicentre exploratory study was conducted at three tertiary hospitals. Patients with nodules >1 cm on CT of the chest were randomised to CT-TTB or Cryo-Radial. With Cryo-Radial, patients had 1–3 cryo-biopsies in addition to at least one R-EBUS biopsy through the 2.6 mm guide sheath. Results: Forty-eight patients were randomised: 22 to CT-TTB and 26 to Cryo-Radial. Sixteen in the CT-TTB and 20 in the Cryo-Radial received the allocated biopsy. The diagnostic yield was CT-TTB 93.8% (15/16) versus Cryo-Radial 85% (17/20) P = 0.61 and the odds ratio was 0.37. For 5/13 (38%), a diagnosis was solely made on cryobiopsy. Eleven (78%) of 14 in CT-TTB versus 7/10 (70%) Cryo-Radial were suitable for EGFR testing P = 0.66, with odds ratio 0.63. Pneumothorax occurrence was 44% (7/16) in CT-TTB versus 4.2% (1/24) in Cryo-Radial. Two (12.5%) of 16 CT-TTB required chest drain insertion. Conclusion: Cryo-Radial is comparable in diagnostic yield and ability to perform EGFR testing with a significantly lower risk of pneumothorax, compared with CT-TTB. Cryo-Radial has the additional advantage of mediastinal staging during the same procedure with Linear-EBUS and is a promising first-line tool in the diagnostic method of lung cancer.

Original languageEnglish
Number of pages9
JournalInternal Medicine Journal
Early online date8 Jun 2022
DOIs
Publication statusE-pub ahead of print - 8 Jun 2022

Keywords

  • bleeding
  • cryo-biopsy
  • CT-guided biopsy
  • diagnostic yield
  • EGFR
  • radial EBUS

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