Criptococosis meníngea en inmunosuprimidos: rol del síndrome inflamatorio de reconstitución inmune

Translated title of the contribution: Cryptococcal meningitis in immunocompromised: Role of the immune reconstitution inflammatory syndrome

Noelia Pontello*, Ezequiel Gleichgerrcht, Manes Facundo, Vladimiro Sinay

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The immune reconstitution inflammatory syndrome (IRIS) is an uncommon but serious complication that increases the morbi-mortality of some patients whose immune status begins to recover following immunosuppressant withdrawal, therefore responding to a previously acquired opportunistic infection. Such response is excessive and worsens the symptoms of the infection, leading to a severe and paradoxical deterioration of clinical status despite appropriate ongoing therapy for the infection. We present the case of a 67-year-old female with immunosuppression following hepatorenal transplantation, who exhibited general deterioration with decrease in food intake, somnolence and headache. She was diagnosed with meningeal cryptococcosis and initiated antifungal treatment with an initial favorable response. Two months after the patient suffered a relapse of her symptoms after which added greater neurological involvement. The present case report identifies the differential diagnoses that should be taken into account in cases similar to the one presented by our patient, highlighting the importance of considering the IRIS.

Translated title of the contributionCryptococcal meningitis in immunocompromised: Role of the immune reconstitution inflammatory syndrome
Original languageSpanish
Pages (from-to)31-34
Number of pages4
JournalNeurologia Argentina
Volume4
Issue number1
DOIs
Publication statusPublished - Jan 2012
Externally publishedYes

Keywords

  • Cryptococcosis
  • Hepatorenal transplantation
  • Immune reconstitution
  • Immune restoration
  • Meningeal cryptococcosis in transplant recipients, Immunosuppression in transplant recipients

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