Abstract
Although Alzheimer’s disease (AD) is the most common cause of dementia in the elderly, a definite diagnosis of AD normally requires post-mortem examination. Without specialised brain scans and other tests that are currently only used for clinical research purposes, the many diagnostic tests that are presently available only result in a diagnosis of ‘probable’ AD. These diagnostic tests are also very time-consuming. This chapter briefly describes the classical post-mortem findings in an AD brain, then discusses the wide variety of current neuropsychological tests, followed by current and developing imaging and biomarker-based clinical diagnostic methods.
Original language | English |
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Title of host publication | Neurodegeneration and Alzheimer’s disease |
Subtitle of host publication | the role of diabetes, genetics, hormones, and lifestyle |
Editors | Ralph N. Martins, Charles S. Brennan, W. M. A. D. Binosha Fernando, Margaret A. Brennan, Stephanie J. Fuller |
Place of Publication | USA |
Publisher | Wiley |
Chapter | 3 |
Pages | 43-87 |
Number of pages | 45 |
ISBN (Electronic) | 9781119356752 |
ISBN (Print) | 9781119356783 |
DOIs | |
Publication status | Published - 11 May 2019 |
Keywords
- Alzheimer’s disease diagnosis
- Cognitive tests
- Dementia
- Magnetic resonance imaging
- Neuroimaging
- Post-mortem examination