Current concepts in Graves' disease

Christian M. Girgis, Bernard L Champion, Jack R. Wall

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)


Graves' disease is the most common cause of hyperthyroidism in the developed world. It is caused by an immune defect in genetically susceptible individuals in whom the production of unique antibodies results in thyroid hormone excess and glandular hyperplasia. When unrecognized, Graves' disease impacts negatively on quality of life and poses serious risks of psychosis, tachyarrhythmia and cardiac failure. Beyond the thyroid, Graves' disease has diverse soft-tissue effects that reflect its systemic autoimmune nature. Thyroid eye disease is the most common of these manifestations and is important to recognise given its risk to vision and potential to deteriorate in response to radioactive iodine ablation. In this review we discuss the investigation and management of Graves' disease, the recent controversy regarding the hepatotoxicity of propylthiouracil and the emergence of novel small-molecule thyroid-stimulating hormone (TSH) receptor ligands as potential targets in the treatment of Graves' disease.

Original languageEnglish
Pages (from-to)135-144
Number of pages10
JournalTherapeutic Advances in Endocrinology and Metabolism
Issue number3
Publication statusPublished - Jun 2011
Externally publishedYes


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