Current sleep disturbance in older people with a lifetime history of depression is associated with increased connectivity in the Default Mode Network

Andrew C. McKinnon, Ian B. Hickie, Jan Scott, Shantel L. Duffy, Louisa Norrie, Zoe Terpening, Ron R. Grunstein, Jim Lagopoulos, Jennifer Batchelor, Simon J. G. Lewis, James M. Shine, Sharon L. Naismith

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Abstract

Background The present study investigated Default Mode Network (DMN) functional connectivity in subjects with a lifetime history of major depression, comparing those with and without current sleep disturbance. Controls were included to assess DMN abnormalities specific to depression. Methods A total of 93 adults aged 50 years and over were recruited from the Healthy Brain Ageing Clinic at the Brain and Mind Centre, Sydney, Australia. The sample comprised two groups, including 22 controls and 71 participants with a lifetime history of DSM-IV major depression (with depressive episode current or remitted). 52 of those with a lifetime history of depression also met criteria for Mild Cognitive Impairment (MCI). Participants underwent resting-state fMRI along with comprehensive psychiatric, neuropsychological, and medical assessment. Subjective sleep quality was assessed via the Pittsburgh Sleep Quality Index (PSQI). Sleep disturbance was defined as a PSQI score > 5. A total of 68% (n = 48) of cases with a lifetime history of depression met criteria for sleep-disturbance. DMN functional connectivity was assessed via ROI-to-ROI analyses. Results Relative to controls, those with lifetime major depression demonstrated significantly increased functional connectivity between the ventromedial prefrontal cortex and the temporal pole. Within the depression group (n = 48), those with current sleep disturbance had significantly increased connectivity between the anterior medial prefrontal cortex and both the parahippocampal cortex and the hippocampal formation, relative to those without sleep disturbance (n = 23). These results were present after controlling for MCI diagnosis. Conclusions Current sleep disturbance together with depression is associated with distinct abnormalities in DMN functioning incorporating regions responsible for self-reflection and declarative memory processes. Impaired sleep is associated with increased connectivity between these regions. Future studies may augment these findings with complementary imaging techniques including cortical thickness and diffusion tensor imaging, as well as high density electroencephalogram recording.

LanguageEnglish
Pages85-94
Number of pages10
JournalJournal of Affective Disorders
Volume229
DOIs
Publication statusPublished - 15 Mar 2018

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Sleep
Depression
Prefrontal Cortex
Diffusion Tensor Imaging
Brain
Diagnostic and Statistical Manual of Mental Disorders
Psychiatry
Electroencephalography
Hippocampus
Magnetic Resonance Imaging

Cite this

McKinnon, Andrew C. ; Hickie, Ian B. ; Scott, Jan ; Duffy, Shantel L. ; Norrie, Louisa ; Terpening, Zoe ; Grunstein, Ron R. ; Lagopoulos, Jim ; Batchelor, Jennifer ; Lewis, Simon J. G. ; Shine, James M. ; Naismith, Sharon L. / Current sleep disturbance in older people with a lifetime history of depression is associated with increased connectivity in the Default Mode Network. In: Journal of Affective Disorders. 2018 ; Vol. 229. pp. 85-94.
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title = "Current sleep disturbance in older people with a lifetime history of depression is associated with increased connectivity in the Default Mode Network",
abstract = "Background The present study investigated Default Mode Network (DMN) functional connectivity in subjects with a lifetime history of major depression, comparing those with and without current sleep disturbance. Controls were included to assess DMN abnormalities specific to depression. Methods A total of 93 adults aged 50 years and over were recruited from the Healthy Brain Ageing Clinic at the Brain and Mind Centre, Sydney, Australia. The sample comprised two groups, including 22 controls and 71 participants with a lifetime history of DSM-IV major depression (with depressive episode current or remitted). 52 of those with a lifetime history of depression also met criteria for Mild Cognitive Impairment (MCI). Participants underwent resting-state fMRI along with comprehensive psychiatric, neuropsychological, and medical assessment. Subjective sleep quality was assessed via the Pittsburgh Sleep Quality Index (PSQI). Sleep disturbance was defined as a PSQI score > 5. A total of 68{\%} (n = 48) of cases with a lifetime history of depression met criteria for sleep-disturbance. DMN functional connectivity was assessed via ROI-to-ROI analyses. Results Relative to controls, those with lifetime major depression demonstrated significantly increased functional connectivity between the ventromedial prefrontal cortex and the temporal pole. Within the depression group (n = 48), those with current sleep disturbance had significantly increased connectivity between the anterior medial prefrontal cortex and both the parahippocampal cortex and the hippocampal formation, relative to those without sleep disturbance (n = 23). These results were present after controlling for MCI diagnosis. Conclusions Current sleep disturbance together with depression is associated with distinct abnormalities in DMN functioning incorporating regions responsible for self-reflection and declarative memory processes. Impaired sleep is associated with increased connectivity between these regions. Future studies may augment these findings with complementary imaging techniques including cortical thickness and diffusion tensor imaging, as well as high density electroencephalogram recording.",
keywords = "Default Mode Network, depression, sleep, resting-state, functional connectivity, ageing",
author = "McKinnon, {Andrew C.} and Hickie, {Ian B.} and Jan Scott and Duffy, {Shantel L.} and Louisa Norrie and Zoe Terpening and Grunstein, {Ron R.} and Jim Lagopoulos and Jennifer Batchelor and Lewis, {Simon J. G.} and Shine, {James M.} and Naismith, {Sharon L.}",
year = "2018",
month = "3",
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doi = "10.1016/j.jad.2017.12.052",
language = "English",
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McKinnon, AC, Hickie, IB, Scott, J, Duffy, SL, Norrie, L, Terpening, Z, Grunstein, RR, Lagopoulos, J, Batchelor, J, Lewis, SJG, Shine, JM & Naismith, SL 2018, 'Current sleep disturbance in older people with a lifetime history of depression is associated with increased connectivity in the Default Mode Network' Journal of Affective Disorders, vol. 229, pp. 85-94. https://doi.org/10.1016/j.jad.2017.12.052

Current sleep disturbance in older people with a lifetime history of depression is associated with increased connectivity in the Default Mode Network. / McKinnon, Andrew C.; Hickie, Ian B.; Scott, Jan; Duffy, Shantel L.; Norrie, Louisa; Terpening, Zoe; Grunstein, Ron R.; Lagopoulos, Jim; Batchelor, Jennifer; Lewis, Simon J. G.; Shine, James M.; Naismith, Sharon L.

In: Journal of Affective Disorders, Vol. 229, 15.03.2018, p. 85-94.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Current sleep disturbance in older people with a lifetime history of depression is associated with increased connectivity in the Default Mode Network

AU - McKinnon,Andrew C.

AU - Hickie,Ian B.

AU - Scott,Jan

AU - Duffy,Shantel L.

AU - Norrie,Louisa

AU - Terpening,Zoe

AU - Grunstein,Ron R.

AU - Lagopoulos,Jim

AU - Batchelor,Jennifer

AU - Lewis,Simon J. G.

AU - Shine,James M.

AU - Naismith,Sharon L.

PY - 2018/3/15

Y1 - 2018/3/15

N2 - Background The present study investigated Default Mode Network (DMN) functional connectivity in subjects with a lifetime history of major depression, comparing those with and without current sleep disturbance. Controls were included to assess DMN abnormalities specific to depression. Methods A total of 93 adults aged 50 years and over were recruited from the Healthy Brain Ageing Clinic at the Brain and Mind Centre, Sydney, Australia. The sample comprised two groups, including 22 controls and 71 participants with a lifetime history of DSM-IV major depression (with depressive episode current or remitted). 52 of those with a lifetime history of depression also met criteria for Mild Cognitive Impairment (MCI). Participants underwent resting-state fMRI along with comprehensive psychiatric, neuropsychological, and medical assessment. Subjective sleep quality was assessed via the Pittsburgh Sleep Quality Index (PSQI). Sleep disturbance was defined as a PSQI score > 5. A total of 68% (n = 48) of cases with a lifetime history of depression met criteria for sleep-disturbance. DMN functional connectivity was assessed via ROI-to-ROI analyses. Results Relative to controls, those with lifetime major depression demonstrated significantly increased functional connectivity between the ventromedial prefrontal cortex and the temporal pole. Within the depression group (n = 48), those with current sleep disturbance had significantly increased connectivity between the anterior medial prefrontal cortex and both the parahippocampal cortex and the hippocampal formation, relative to those without sleep disturbance (n = 23). These results were present after controlling for MCI diagnosis. Conclusions Current sleep disturbance together with depression is associated with distinct abnormalities in DMN functioning incorporating regions responsible for self-reflection and declarative memory processes. Impaired sleep is associated with increased connectivity between these regions. Future studies may augment these findings with complementary imaging techniques including cortical thickness and diffusion tensor imaging, as well as high density electroencephalogram recording.

AB - Background The present study investigated Default Mode Network (DMN) functional connectivity in subjects with a lifetime history of major depression, comparing those with and without current sleep disturbance. Controls were included to assess DMN abnormalities specific to depression. Methods A total of 93 adults aged 50 years and over were recruited from the Healthy Brain Ageing Clinic at the Brain and Mind Centre, Sydney, Australia. The sample comprised two groups, including 22 controls and 71 participants with a lifetime history of DSM-IV major depression (with depressive episode current or remitted). 52 of those with a lifetime history of depression also met criteria for Mild Cognitive Impairment (MCI). Participants underwent resting-state fMRI along with comprehensive psychiatric, neuropsychological, and medical assessment. Subjective sleep quality was assessed via the Pittsburgh Sleep Quality Index (PSQI). Sleep disturbance was defined as a PSQI score > 5. A total of 68% (n = 48) of cases with a lifetime history of depression met criteria for sleep-disturbance. DMN functional connectivity was assessed via ROI-to-ROI analyses. Results Relative to controls, those with lifetime major depression demonstrated significantly increased functional connectivity between the ventromedial prefrontal cortex and the temporal pole. Within the depression group (n = 48), those with current sleep disturbance had significantly increased connectivity between the anterior medial prefrontal cortex and both the parahippocampal cortex and the hippocampal formation, relative to those without sleep disturbance (n = 23). These results were present after controlling for MCI diagnosis. Conclusions Current sleep disturbance together with depression is associated with distinct abnormalities in DMN functioning incorporating regions responsible for self-reflection and declarative memory processes. Impaired sleep is associated with increased connectivity between these regions. Future studies may augment these findings with complementary imaging techniques including cortical thickness and diffusion tensor imaging, as well as high density electroencephalogram recording.

KW - Default Mode Network

KW - depression

KW - sleep

KW - resting-state

KW - functional connectivity

KW - ageing

UR - http://www.scopus.com/inward/record.url?scp=85040012395&partnerID=8YFLogxK

U2 - 10.1016/j.jad.2017.12.052

DO - 10.1016/j.jad.2017.12.052

M3 - Article

VL - 229

SP - 85

EP - 94

JO - Journal of Affective Disorders

T2 - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -