Current status on histological classification in Cushing’s disease

Luis V. Syro*, Fabio Rotondo, Michael D. Cusimano, Antonio Di Ieva, Eva Horvath, Lina M. Restrepo, Min Wong, Donald W. Killinger, Harley Smyth, Kalman Kovacs

*Corresponding author for this work

Research output: Contribution to journalReview article

11 Citations (Scopus)


Introduction: Managing Cushing’s disease remains a challenge. Surgery is the first option of treatment and it offers a high success rate. Even in cases where biochemical remission is not achieved, it is crucial to obtain surgical tissue for morphological diagnosis because the therapeutic approach can be modified according to the findings.Materials and Methods: A literature search was performed using PubMed for information regarding pathology and Cushing’s disease.Results: The histopathological features found in the pituitary gland of patients with Cushing’s disease are presented.Conclusion: Different subtypes of ACTH-producing pituitary tumors are recognized and characterized. The significance of finding a normal pituitary gland with or without Crooke’s changes is also discussed.

Original languageEnglish
Pages (from-to)217-224
Number of pages8
Issue number2
Publication statusPublished - 1 Apr 2015
Externally publishedYes


  • Classification
  • Cushing’s disease
  • Diagnosis
  • Pathology
  • Pituitary tumor

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