Current understanding of fear learning and memory in humans and animal models and the value of a linguistic approach for analyzing fear learning and memory in humans

Jacob Raber, Shahar Arzy, Julie Boulanger Bertolus, Brendan Depue, Haley E. Haas, Stefan G. Hofmann, Maria Kangas, Elizabeth Kensinger, Christopher A. Lowry, Hilary A. Marusak, Jessica Minnier, Anne Marie Mouly, Andreas Mühlberger, Seth Davin Norrholm, Kirsi Peltonen, Graziano Pinna, Christine Rabinak, Youssef Shiban, Hermona Soreq, Michael A. van der Kooij & 4 others Leroy Lowe, Leah T. Weingast, Paula Yamashita, Sydney Weber Boutros

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

Fear is an emotion that serves as a driving factor in how organisms move through the world. In this review, we discuss the current understandings of the subjective experience of fear and the related biological processes involved in fear learning and memory. We first provide an overview of fear learning and memory in humans and animal models, encompassing the neurocircuitry and molecular mechanisms, the influence of genetic and environmental factors, and how fear learning paradigms have contributed to treatments for fear-related disorders, such as posttraumatic stress disorder. Current treatments as well as novel strategies, such as targeting the perisynaptic environment and use of virtual reality, are addressed. We review research on the subjective experience of fear and the role of autobiographical memory in fear-related disorders. We also discuss the gaps in our understanding of fear learning and memory, and the degree of consensus in the field. Lastly, the development of linguistic tools for assessments and treatment of fear learning and memory disorders is discussed.

LanguageEnglish
Pages136-177
Number of pages42
JournalNeuroscience and Biobehavioral Reviews
Volume105
DOIs
Publication statusPublished - Oct 2019

Fingerprint

Linguistics
Fear
Animal Models
Learning
Biological Phenomena
Episodic Memory
Learning Disorders
Memory Disorders
Post-Traumatic Stress Disorders
Consensus
Emotions

Bibliographical note

Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • fear
  • virtual reality
  • linguistics
  • autobiography
  • subjective fear
  • neuroanatomy
  • neuropharmacology

Cite this

Raber, Jacob ; Arzy, Shahar ; Bertolus, Julie Boulanger ; Depue, Brendan ; Haas, Haley E. ; Hofmann, Stefan G. ; Kangas, Maria ; Kensinger, Elizabeth ; Lowry, Christopher A. ; Marusak, Hilary A. ; Minnier, Jessica ; Mouly, Anne Marie ; Mühlberger, Andreas ; Norrholm, Seth Davin ; Peltonen, Kirsi ; Pinna, Graziano ; Rabinak, Christine ; Shiban, Youssef ; Soreq, Hermona ; van der Kooij, Michael A. ; Lowe, Leroy ; Weingast, Leah T. ; Yamashita, Paula ; Boutros, Sydney Weber. / Current understanding of fear learning and memory in humans and animal models and the value of a linguistic approach for analyzing fear learning and memory in humans. In: Neuroscience and Biobehavioral Reviews. 2019 ; Vol. 105. pp. 136-177.
@article{25035bb3fca3418ab9bbb6b9e838b4fa,
title = "Current understanding of fear learning and memory in humans and animal models and the value of a linguistic approach for analyzing fear learning and memory in humans",
abstract = "Fear is an emotion that serves as a driving factor in how organisms move through the world. In this review, we discuss the current understandings of the subjective experience of fear and the related biological processes involved in fear learning and memory. We first provide an overview of fear learning and memory in humans and animal models, encompassing the neurocircuitry and molecular mechanisms, the influence of genetic and environmental factors, and how fear learning paradigms have contributed to treatments for fear-related disorders, such as posttraumatic stress disorder. Current treatments as well as novel strategies, such as targeting the perisynaptic environment and use of virtual reality, are addressed. We review research on the subjective experience of fear and the role of autobiographical memory in fear-related disorders. We also discuss the gaps in our understanding of fear learning and memory, and the degree of consensus in the field. Lastly, the development of linguistic tools for assessments and treatment of fear learning and memory disorders is discussed.",
keywords = "fear, virtual reality, linguistics, autobiography, subjective fear, neuroanatomy, neuropharmacology",
author = "Jacob Raber and Shahar Arzy and Bertolus, {Julie Boulanger} and Brendan Depue and Haas, {Haley E.} and Hofmann, {Stefan G.} and Maria Kangas and Elizabeth Kensinger and Lowry, {Christopher A.} and Marusak, {Hilary A.} and Jessica Minnier and Mouly, {Anne Marie} and Andreas M{\"u}hlberger and Norrholm, {Seth Davin} and Kirsi Peltonen and Graziano Pinna and Christine Rabinak and Youssef Shiban and Hermona Soreq and {van der Kooij}, {Michael A.} and Leroy Lowe and Weingast, {Leah T.} and Paula Yamashita and Boutros, {Sydney Weber}",
note = "Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",
year = "2019",
month = "10",
doi = "10.1016/j.neubiorev.2019.03.015",
language = "English",
volume = "105",
pages = "136--177",
journal = "Neuroscience and Biobehavioral Reviews",
issn = "0149-7634",
publisher = "Elsevier",

}

Raber, J, Arzy, S, Bertolus, JB, Depue, B, Haas, HE, Hofmann, SG, Kangas, M, Kensinger, E, Lowry, CA, Marusak, HA, Minnier, J, Mouly, AM, Mühlberger, A, Norrholm, SD, Peltonen, K, Pinna, G, Rabinak, C, Shiban, Y, Soreq, H, van der Kooij, MA, Lowe, L, Weingast, LT, Yamashita, P & Boutros, SW 2019, 'Current understanding of fear learning and memory in humans and animal models and the value of a linguistic approach for analyzing fear learning and memory in humans' Neuroscience and Biobehavioral Reviews, vol. 105, pp. 136-177. https://doi.org/10.1016/j.neubiorev.2019.03.015

Current understanding of fear learning and memory in humans and animal models and the value of a linguistic approach for analyzing fear learning and memory in humans. / Raber, Jacob; Arzy, Shahar; Bertolus, Julie Boulanger; Depue, Brendan; Haas, Haley E.; Hofmann, Stefan G.; Kangas, Maria; Kensinger, Elizabeth; Lowry, Christopher A.; Marusak, Hilary A.; Minnier, Jessica; Mouly, Anne Marie; Mühlberger, Andreas; Norrholm, Seth Davin; Peltonen, Kirsi; Pinna, Graziano; Rabinak, Christine; Shiban, Youssef; Soreq, Hermona; van der Kooij, Michael A.; Lowe, Leroy; Weingast, Leah T.; Yamashita, Paula; Boutros, Sydney Weber.

In: Neuroscience and Biobehavioral Reviews, Vol. 105, 10.2019, p. 136-177.

Research output: Contribution to journalReview articleResearchpeer-review

TY - JOUR

T1 - Current understanding of fear learning and memory in humans and animal models and the value of a linguistic approach for analyzing fear learning and memory in humans

AU - Raber,Jacob

AU - Arzy,Shahar

AU - Bertolus,Julie Boulanger

AU - Depue,Brendan

AU - Haas,Haley E.

AU - Hofmann,Stefan G.

AU - Kangas,Maria

AU - Kensinger,Elizabeth

AU - Lowry,Christopher A.

AU - Marusak,Hilary A.

AU - Minnier,Jessica

AU - Mouly,Anne Marie

AU - Mühlberger,Andreas

AU - Norrholm,Seth Davin

AU - Peltonen,Kirsi

AU - Pinna,Graziano

AU - Rabinak,Christine

AU - Shiban,Youssef

AU - Soreq,Hermona

AU - van der Kooij,Michael A.

AU - Lowe,Leroy

AU - Weingast,Leah T.

AU - Yamashita,Paula

AU - Boutros,Sydney Weber

N1 - Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2019/10

Y1 - 2019/10

N2 - Fear is an emotion that serves as a driving factor in how organisms move through the world. In this review, we discuss the current understandings of the subjective experience of fear and the related biological processes involved in fear learning and memory. We first provide an overview of fear learning and memory in humans and animal models, encompassing the neurocircuitry and molecular mechanisms, the influence of genetic and environmental factors, and how fear learning paradigms have contributed to treatments for fear-related disorders, such as posttraumatic stress disorder. Current treatments as well as novel strategies, such as targeting the perisynaptic environment and use of virtual reality, are addressed. We review research on the subjective experience of fear and the role of autobiographical memory in fear-related disorders. We also discuss the gaps in our understanding of fear learning and memory, and the degree of consensus in the field. Lastly, the development of linguistic tools for assessments and treatment of fear learning and memory disorders is discussed.

AB - Fear is an emotion that serves as a driving factor in how organisms move through the world. In this review, we discuss the current understandings of the subjective experience of fear and the related biological processes involved in fear learning and memory. We first provide an overview of fear learning and memory in humans and animal models, encompassing the neurocircuitry and molecular mechanisms, the influence of genetic and environmental factors, and how fear learning paradigms have contributed to treatments for fear-related disorders, such as posttraumatic stress disorder. Current treatments as well as novel strategies, such as targeting the perisynaptic environment and use of virtual reality, are addressed. We review research on the subjective experience of fear and the role of autobiographical memory in fear-related disorders. We also discuss the gaps in our understanding of fear learning and memory, and the degree of consensus in the field. Lastly, the development of linguistic tools for assessments and treatment of fear learning and memory disorders is discussed.

KW - fear

KW - virtual reality

KW - linguistics

KW - autobiography

KW - subjective fear

KW - neuroanatomy

KW - neuropharmacology

UR - http://www.scopus.com/inward/record.url?scp=85068435428&partnerID=8YFLogxK

U2 - 10.1016/j.neubiorev.2019.03.015

DO - 10.1016/j.neubiorev.2019.03.015

M3 - Review article

VL - 105

SP - 136

EP - 177

JO - Neuroscience and Biobehavioral Reviews

T2 - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

SN - 0149-7634

ER -