TY - JOUR
T1 - Current understanding of fear learning and memory in humans and animal models and the value of a linguistic approach for analyzing fear learning and memory in humans
AU - Raber, Jacob
AU - Arzy, Shahar
AU - Bertolus, Julie Boulanger
AU - Depue, Brendan
AU - Haas, Haley E.
AU - Hofmann, Stefan G.
AU - Kangas, Maria
AU - Kensinger, Elizabeth
AU - Lowry, Christopher A.
AU - Marusak, Hilary A.
AU - Minnier, Jessica
AU - Mouly, Anne Marie
AU - Mühlberger, Andreas
AU - Norrholm, Seth Davin
AU - Peltonen, Kirsi
AU - Pinna, Graziano
AU - Rabinak, Christine
AU - Shiban, Youssef
AU - Soreq, Hermona
AU - van der Kooij, Michael A.
AU - Lowe, Leroy
AU - Weingast, Leah T.
AU - Yamashita, Paula
AU - Boutros, Sydney Weber
N1 - Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
PY - 2019/10
Y1 - 2019/10
N2 - Fear is an emotion that serves as a driving factor in how organisms move through the world. In this review, we discuss the current understandings of the subjective experience of fear and the related biological processes involved in fear learning and memory. We first provide an overview of fear learning and memory in humans and animal models, encompassing the neurocircuitry and molecular mechanisms, the influence of genetic and environmental factors, and how fear learning paradigms have contributed to treatments for fear-related disorders, such as posttraumatic stress disorder. Current treatments as well as novel strategies, such as targeting the perisynaptic environment and use of virtual reality, are addressed. We review research on the subjective experience of fear and the role of autobiographical memory in fear-related disorders. We also discuss the gaps in our understanding of fear learning and memory, and the degree of consensus in the field. Lastly, the development of linguistic tools for assessments and treatment of fear learning and memory disorders is discussed.
AB - Fear is an emotion that serves as a driving factor in how organisms move through the world. In this review, we discuss the current understandings of the subjective experience of fear and the related biological processes involved in fear learning and memory. We first provide an overview of fear learning and memory in humans and animal models, encompassing the neurocircuitry and molecular mechanisms, the influence of genetic and environmental factors, and how fear learning paradigms have contributed to treatments for fear-related disorders, such as posttraumatic stress disorder. Current treatments as well as novel strategies, such as targeting the perisynaptic environment and use of virtual reality, are addressed. We review research on the subjective experience of fear and the role of autobiographical memory in fear-related disorders. We also discuss the gaps in our understanding of fear learning and memory, and the degree of consensus in the field. Lastly, the development of linguistic tools for assessments and treatment of fear learning and memory disorders is discussed.
KW - fear
KW - virtual reality
KW - linguistics
KW - autobiography
KW - subjective fear
KW - neuroanatomy
KW - neuropharmacology
UR - http://www.scopus.com/inward/record.url?scp=85068435428&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2019.03.015
DO - 10.1016/j.neubiorev.2019.03.015
M3 - Review article
C2 - 30970272
AN - SCOPUS:85068435428
SN - 0149-7634
VL - 105
SP - 136
EP - 177
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
ER -