Current understanding of the molecular mechanisms of kidney cancer: a primer for urologists

Darwin L. Lim, Raymond Ko, Stephen E. Pautler

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)

Abstract

Renal cell carcinoma (RCC), the fifth leading malignant condition for men and tenth for women, accounts for 3% of all malignancies in Canada. It is a heterogeneous epithelial malignancy with different subtypes and varied tumour biology. Although most cases of RCC are sporadic, up to 4% of patients have an inherited predisposition for the disease. In this article, we review the current molecular genetics of the different subtypes in hereditary and sporadic RCC. Significant developments in understanding the underlying genetic basis of RCC over the last 2 decades are attributed to intensive research about rare inherited renal cancer syndromes and the identification of the genes responsible for them. Many of these genes are also found in sporadic RCC. Understanding the molecular mechanisms involved in the pathogenesis of RCC has aided the development of molecular-targeted drugs for this disease.

Original languageEnglish
Pages (from-to)S13-S20
Number of pages8
JournalJournal of the Canadian Urological Association
Volume1
Issue number2 SUPPL
Publication statusPublished - Jun 2007

Keywords

  • LINDAU TUMOR-SUPPRESSOR
  • RENAL-CELL CARCINOMA
  • HEPATOCYTE GROWTH-FACTOR
  • HOGG-DUBE-SYNDROME
  • NUCLEAR-CYTOPLASMIC TRAFFICKING
  • MET PROTOONCOGENE PRODUCT
  • RECEPTOR TYROSINE KINASE
  • PROMOTES INVASIVE GROWTH
  • GENE-PRODUCT
  • EPITHELIAL-CELLS

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