TY - JOUR
T1 - Cyclin F
T2 - a component of an E3 ubiquitin ligase complex with roles in neurodegeneration and cancer
AU - Galper, Jasmin
AU - Rayner, Stephanie L.
AU - Hogan, Alison L.
AU - Fifita, Jennifer A.
AU - Lee, Albert
AU - Chung, Roger S.
AU - Blair, Ian P.
AU - Yang, Shu
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Cyclin F, encoded by CCNF, is the substrate recognition component of the Skp1-Cul1-F-box E3 ubiquitin ligase complex, SCFcyclin F. E3 ubiquitin ligases play a key role in ubiquitin-proteasome mediated protein degradation, an essential component of protein homeostatic mechanisms within the cell. By recognising and regulating the availability of several protein substrates, SCFcyclin F plays a role in regulating various cellular processes including replication and repair of DNA and cell cycle checkpoint control. Cyclin F dysfunction has been implicated in various forms of cancer and CCNF mutations were recently linked to familial and sporadic amyotrophic lateral sclerosis and frontotemporal dementia, offering a new lead to understanding the pathogenic mechanisms underlying neurodegeneration. In this review, we evaluate the current literature on the function of cyclin F with an emphasis on its roles in cancer and neurodegeneration.
AB - Cyclin F, encoded by CCNF, is the substrate recognition component of the Skp1-Cul1-F-box E3 ubiquitin ligase complex, SCFcyclin F. E3 ubiquitin ligases play a key role in ubiquitin-proteasome mediated protein degradation, an essential component of protein homeostatic mechanisms within the cell. By recognising and regulating the availability of several protein substrates, SCFcyclin F plays a role in regulating various cellular processes including replication and repair of DNA and cell cycle checkpoint control. Cyclin F dysfunction has been implicated in various forms of cancer and CCNF mutations were recently linked to familial and sporadic amyotrophic lateral sclerosis and frontotemporal dementia, offering a new lead to understanding the pathogenic mechanisms underlying neurodegeneration. In this review, we evaluate the current literature on the function of cyclin F with an emphasis on its roles in cancer and neurodegeneration.
KW - cyclin F
KW - ubiquitin proteasome system
KW - E3 ubiquitin ligase
KW - amyotrophic lateral sclerosis
KW - cancer
UR - http://www.scopus.com/inward/record.url?scp=85022073559&partnerID=8YFLogxK
U2 - 10.1016/j.biocel.2017.06.011
DO - 10.1016/j.biocel.2017.06.011
M3 - Article
C2 - 28652210
VL - 89
SP - 216
EP - 220
JO - International Journal of Biochemistry and Cell Biology
JF - International Journal of Biochemistry and Cell Biology
SN - 1357-2725
ER -