Cystogenesis precedes cardiovascular disease in a rat model of autosomal recessive polycystic kidney disease

J. D. Coombes, K. Ghatora, R. Loxley, Y. S. Tan, J. K. Phillips, G. K. Rangan

Research output: Contribution to journalMeeting abstractpeer-review


Background: The Lew/SSNArc (LPK) rat is a unique model of spontaneous polycystic kidney disease (PKD) which is associated with cardiovascular disease. The aims of this study were to determine: (i) the nephron-segment origin of the cysts and (ii) whether cyst formation is a precursor to cardiovascular disease in this model. Methods: Cyst formation, renal function, systolic blood pressure and left ventricular hypertrophy (LVH) were examined in LPK rats and compared with Lewis controls (1,3,6,12 and 24 wks). Immunohistochemistry for nephron segmentspecific markers [aquaporin (AQP)-1, AQP-2, and Tamm-Horsfall protein (THP)] was performed. Results: Kidney enlargement was reniform and cystogenesis occurred predominantly during the early postnatal period (between 1–3 wks of age). Epithelial cells of cysts were positive for AQP-2 and THP, whereas AQP-1 staining was rare. LPK rats developed hypertension at 6 wks, decreased renal function and increased cardiac mass by 12 wks, and LVH at 24 wks (all p < 0.05). Conclusions: Cysts in LPK rats arise from collecting ducts and distal convoluted tubules probably due to defects in postnatal nephron maturation, in a manner that phenotypically resembles autosomal recessive PKD in humans. This study also supports the hypothesis that cystogenesis is a precursor to hypertension and cardiovascular disease in PKD.
Original languageEnglish
Article number1198
Pages (from-to)A50-A50
Number of pages1
Issue numberSupplement s2
Publication statusPublished - Sept 2007
Externally publishedYes
Event43rd Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology - Gold Coast, Australia
Duration: 8 Sept 200712 Sept 2007


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