Cytokines and matrix metalloproteinases mRNA expression in archival human tissues from failed total hip arthroplasty using in situ hybridization and color video image analysis

Y. Yu, W. R. Walsh*, D. H. Sonnabend, J. L. Yang, F. Bonar, B. Markovic, W. Bruce, L. Kohan, M. Neil

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Reports on the histological and biochemical nature of periprosthetic fibrous/granulomatous tissue has, to date, been largely limited to frozen tissue sections. This study reports the cytokine and matrix metalloproteinase profiles found in periprosthetic interface tissues in THA which have failed due to aseptic loosening and in capsular tissues obtained at primary surgery. The study employs immunohistochemistry, in situ hybridization, and color video image analysis on formalin fixed and paraffin embedded sections.

Original languageEnglish
Pages (from-to)23-29
Number of pages7
JournalBulletin: Hospital for Joint Diseases
Volume57
Issue number1
Publication statusPublished - 1998
Externally publishedYes

Keywords

  • Arthroplasty, Hip prosthesis
  • Cytokines
  • In situ hybridization
  • Matrix metalloproteinases

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