Cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal carcinomatosis from colorectal carcinoma

non-mucinous tumour associated with an improved survival

T. D. Yan, F. Chu, M. Links, P. C. Kam, D. Glenn, D. L. Morris*

*Corresponding author for this work

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Aims: Cytoreductive surgery combined with perioperative intraperitoneal chemotherapy has been reported as a treatment option for patients with peritoneal carcinomatosis from colorectal carcinoma. Methods: Thirty patients with colorectal peritoneal carcinomatosis underwent cytoreductive surgery and perioperative intraperitoneal chemotherapy. All appendiceal cancers were excluded. All patients were followed until January 2006 or death. Univariate analysis was performed to evaluate significant prognostic factors for overall survival, defined from the time of surgery. Results: There were 13 male patients. The mean age at the time of surgery was 54 years. There was no hospital mortality. The mean duration of hospital stay was 27 days. The overall median survival was 29 months, with 1- and 2-year survival of 72% and 64%, respectively. Twenty-one patients had complete cytoreduction and their 1- and 2-year survival rates were 85% and 71%, respectively. Univariate analysis demonstrated that patients with non-mucinous colorectal adenocarcinoma, Peritoneal Cancer Index (PCI) ≤13, and complete cytoreduction were associated with an improved survival. Conclusions: This study reported on 30 patients who underwent cytoreductive surgery and perioperative intraperitoneal chemotherapy for colorectal peritoneal carcinomatosis. Patients with mucinous tumour had relatively more extensive intraperitoneal disease. Non-mucinous colorectal adenocarcinoma, PCI ≤13, and complete cytoreduction were associated with an improved survival.

Original languageEnglish
Pages (from-to)1119-1124
Number of pages6
JournalEuropean Journal of Surgical Oncology
Volume32
Issue number10
DOIs
Publication statusPublished - Dec 2006
Externally publishedYes

Keywords

  • Colorectal carcinoma
  • Cytoreductive surgery
  • Intraperitoneal chemotherapy
  • Peritoneal carcinomatosis
  • Peritoneal surface malignancy

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