@inproceedings{1ad775c401c24f26b28e2d2f11ed94f4,
title = "Data visualization of CRISPR-Cas9 guide RNA design tools",
abstract = "With the advancement of genomic engineering and genetic modification techniques, the uptake of computational tools to design guide RNA increased drastically. Searching for genomic targets to design guides with maximum on-target activity (efficiency) and minimum off-target activity (specificity) is now an essential part of genome editing experiments. Today, a variety of tools exist that allow the search of genomic targets and let users customize their search parameters to better suit their experiments. Here we present an overview of different ways to visualize these searched CRISPR target sites along with specific downstream information like primer design, restriction enzyme activity and mutational outcome prediction after a double-stranded break. We discuss the importance of a good visualization summary to interpret information along with different ways to represent similar information effectively.",
keywords = "CRISPR-Cas9, design tools, gRNA, knock-out, UX design, Visualization",
author = "Yatish Jain and Izzath, {Fathima Afra Mohamed} and Wilson, {Laurence O. W.} and Bauer, {Denis C.}",
note = "Copyright 2024 International Medical Informatics Association (IMIA) and IOS Press. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.; 19th World Congress on Medical and Health Informatics, MedInfo 2023 ; Conference date: 08-07-2023 Through 12-07-2023",
year = "2024",
month = jan,
day = "25",
doi = "10.3233/SHTI231069",
language = "English",
isbn = "9781643684567",
series = "Studies in Health Technology and Informatics",
publisher = "IOS Press",
pages = "770--774",
editor = "Jen Bichel-Findlay and Paula Otero and Philip Scott and Elaine Huesing",
booktitle = "MEDINFO 2023 - The Future is Accessible",
address = "Netherlands",
}