@article{96fcefc7a2c04b029efed97f978ddfd5,
title = "Day or overnight transfusion in critically ill patients: does it matter?",
abstract = "Background and objectives: The timing of blood administration in critically ill patients is first driven by patients' needs. This study aimed to define the epidemiology and significance of overnight transfusion in critically ill patients. Materials and methods: This is a post hoc analysis of a prospective multicentre observational study including 874 critically ill patients receiving red blood cells, platelets, fresh frozen plasma (FFP) or cryoprecipitate. Characteristics of patients receiving blood only during the day (8 am up until 8 pm) were compared to those receiving blood only overnight (8 pm up until 8 am). Characteristics of transfusion were compared, and factors independently associated with major bleeding were analysed. Results: The 287 patients transfused during the day only had similar severity and mortality to the 258 receiving blood products overnight only. Although bleeding-related admission diagnoses were similar, major bleeding was the indication for transfusion in 12% of patients transfused in daytime only versus 30% of patients transfused at night only (P < 0·001). Similar total amount of blood products were transfused at day and night (2856 versus 2927); however, patients were more likely to receive FFP and cryoprecipitate at night compared with daytime. Overnight transfusion was independently associated with increased odds of major bleeding (odds ratio, 3·16, 95% confidence interval, 2·00–5·01). Conclusion: Transfusion occurs evenly across day and night in ICU; nonetheless, there are differences in type of blood products administered that reflect differences in indication. Critically ill patients were more likely to receive blood for major bleeding at night irrespective of admission diagnosis.",
keywords = "critically ill patient, major bleeding, outcome, red blood cells, timing of care, transfusion",
author = "C. Aubron and Kandane-Rathnayake, {R. K.} and N. Andrianopoulos and A. Westbrook and S. Engelbrecht and I. Ozolins and M. Bailey and L. Murray and Cooper, {D. J.} and Wood, {E. M.} and McQuilten, {Z. K.} and {The Blood Observational Study investigators} and V. Pettil{\"a} and A. Nichol and Phillips, {L. E.} and A. Street and C. French and N. Orford and J. Santamaria and R. Bellomo and S. Vallance and C. McArthur and S. McGuiness and L. Newby and C. Simmonds and R. Parke and H. Buhr and D. Goldsmith and K. O'Sullivan and I. Mercer and R. Gazzard and C. Tauschke and D. Hill and J. Fletcher and C. Boschert and G. Koch and D. Ernest and S. Eliott and F. Hawker and B. Howe and K. Ellem and K. Duff and J. Mehrtens and S. Henderson and D. Milliss and B. O'Bree and K. Shepherd and B. Ihle and S. Ho and M. Graan and A. Bernsten and E. Ryan and J. Botha and J. Vuat and A. Kinmonth and M. Fraser and B. Richards and M. Tallott and R. Whitbread and R. Freebairn and L. Thomas and M. Parr and S. Micallef and K. Deshpande and J. Wood and T. Williams and J. Tai and A. Boase and P. Galt and B. King and R. Price and J. Tomlinson and L. Cole and I. Seppelt and L. Weisbrodt and R. Gresham and M. Nikas and J. Laing and J. Bell and G. McHugh and D. Hancock and S. Kirkham and Y. Shehabi and M. Campbell and V. Stockdale and S. Peake and P. Williams and P. Sharley and S. O'Connor and D. Stephens and J. Thomas and R. Sistla and R. McAllister and K. Marsden and C. MacIsaac and D. Barge and T. Caf and S. Finfer and L. Tan and S. Bird and S. Webb and J. Chamberlain and G. McEntaggart and A. Gould and R. Totaro and D. Rajbhandari and S. Baker and B. Roberts and P. Lavercombe and R. Walker and J. Myburgh and V. Dhiacou and R. Smith and J. Holmes and P. Nair and C. Burns and T. Browne and J. Goodson and {van Haren}, F. and {La Pine}, M. and G. Hart and J. Broadbent and P. Hicks and D. Mackle and L. Andrews and H. Raunow and L. Keen and A. Davey-Quinn and F. Hill and R. Xu and {The ANZICS Clinical Trials Group}",
year = "2018",
month = apr,
day = "4",
doi = "10.1111/vox.12635",
language = "English",
volume = "113",
pages = "275--282",
journal = "Vox Sanguinis",
issn = "0042-9007",
publisher = "Wiley-Blackwell, Wiley",
number = "3",
}