TY - JOUR
T1 - Decision-making cognition in neurodegenerative diseases
AU - Gleichgerrcht, Ezequiel
AU - Ibáñez, Agustín
AU - Roca, María
AU - Torralva, Teresa
AU - Manes, Facundo
PY - 2010/11
Y1 - 2010/11
N2 - A large proportion of human social neuroscience research has focused on the issue of decision-making. Impaired decision-making is a symptomatic feature of a number of neurodegenerative diseases, but the nature of these decision-making deficits depends on the particular disease. Thus, examining the qualitative differences in decision-making impairments associated with different neurodegenerative diseases could provide valuable information regarding the underlying neural basis of decision-making. Nevertheless, few comparative reports of decision-making across patient groups exist. In this Review, we examine the neuroanatomical substrates of decision-making in relation to the neuropathological changes that occur in Alzheimer disease, frontotemporal dementia, Parkinson disease and Huntington disease. We then examine the main findings from studies of decision-making in these neurodegenerative diseases. Finally, we suggest a number of recommendations that future studies could adopt to aid our understanding of decision-making cognition.
AB - A large proportion of human social neuroscience research has focused on the issue of decision-making. Impaired decision-making is a symptomatic feature of a number of neurodegenerative diseases, but the nature of these decision-making deficits depends on the particular disease. Thus, examining the qualitative differences in decision-making impairments associated with different neurodegenerative diseases could provide valuable information regarding the underlying neural basis of decision-making. Nevertheless, few comparative reports of decision-making across patient groups exist. In this Review, we examine the neuroanatomical substrates of decision-making in relation to the neuropathological changes that occur in Alzheimer disease, frontotemporal dementia, Parkinson disease and Huntington disease. We then examine the main findings from studies of decision-making in these neurodegenerative diseases. Finally, we suggest a number of recommendations that future studies could adopt to aid our understanding of decision-making cognition.
UR - http://www.scopus.com/inward/record.url?scp=78149414985&partnerID=8YFLogxK
U2 - 10.1038/nrneurol.2010.148
DO - 10.1038/nrneurol.2010.148
M3 - Review article
C2 - 21045795
AN - SCOPUS:78149414985
SN - 1759-4758
VL - 6
SP - 611
EP - 623
JO - Nature Reviews Neurology
JF - Nature Reviews Neurology
IS - 11
ER -