Deconvolution of overlapping cortical auditory evoked potentials recorded using short stimulus onset-asynchrony ranges

Fabrice Bardy*, Bram Van Dun, Harvey Dillon, Catherine M. McMahon

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)


    Objective: The first aim of this study is to validate the theoretical framework of least-squares (LS) deconvolution on experimental data. The second is to investigate the waveform morphology of the cortical auditory evoked potential (CAEP) for five stimulus onset-asynchronies (SOAs) and effects of alternating stimulus frequency in normally hearing adults. Methods: Eleven adults (19-55. years) with normal hearing were investigated using tone-burst stimuli of 500 and 2000. Hz with SOAs jittered around 150, 250, 450, and 850. ms in a paired-interval paradigm with fixed or alternating stimulus frequency. Results: The LS deconvolution technique disentangled the overlapping responses, which then provided the following insights. The CAEP amplitude reached a minimum value for SOAs jittered around 450. ms, in contrast with significantly larger amplitudes for SOAs jittered around 150 and 850. ms. Despite this, longer latencies of N1 and P2 consistently occurred for decreasing SOAs. Alternating stimulus frequency significantly increased the amplitude of the CAEP response and decreased latencies for SOAs jittered around 150. ms. Effects of SOAs and alternating stimuli on CAEP amplitude can be modelled using a quantitative model of latent inhibition. Conclusions: LS deconvolution allows correction for cortical response overlap. The amplitude of the CAEP is sensitive to SOA and stimulus frequency alternation. Significance: CAEPs are emerging as an important tool in the objective evaluation of hearing aid and cochlear implant fittings. Responses to closely spaced stimuli provide objective information about integration and inhibition mechanisms in the auditory cortex.

    Original languageEnglish
    Pages (from-to)814-826
    Number of pages13
    JournalClinical Neurophysiology
    Issue number4
    Publication statusPublished - Apr 2014


    • Alternating stimulus frequency
    • Cortical auditory evoked potential
    • Electroencephalography
    • Least-squares deconvolution
    • Stimulus onset-asynchrony


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