TY - JOUR
T1 - Deconvolution of overlapping cortical auditory evoked potentials recorded using short stimulus onset-asynchrony ranges
AU - Bardy, Fabrice
AU - Van Dun, Bram
AU - Dillon, Harvey
AU - McMahon, Catherine M.
PY - 2014/4
Y1 - 2014/4
N2 - Objective: The first aim of this study is to validate the theoretical framework of least-squares (LS) deconvolution on experimental data. The second is to investigate the waveform morphology of the cortical auditory evoked potential (CAEP) for five stimulus onset-asynchronies (SOAs) and effects of alternating stimulus frequency in normally hearing adults. Methods: Eleven adults (19-55. years) with normal hearing were investigated using tone-burst stimuli of 500 and 2000. Hz with SOAs jittered around 150, 250, 450, and 850. ms in a paired-interval paradigm with fixed or alternating stimulus frequency. Results: The LS deconvolution technique disentangled the overlapping responses, which then provided the following insights. The CAEP amplitude reached a minimum value for SOAs jittered around 450. ms, in contrast with significantly larger amplitudes for SOAs jittered around 150 and 850. ms. Despite this, longer latencies of N1 and P2 consistently occurred for decreasing SOAs. Alternating stimulus frequency significantly increased the amplitude of the CAEP response and decreased latencies for SOAs jittered around 150. ms. Effects of SOAs and alternating stimuli on CAEP amplitude can be modelled using a quantitative model of latent inhibition. Conclusions: LS deconvolution allows correction for cortical response overlap. The amplitude of the CAEP is sensitive to SOA and stimulus frequency alternation. Significance: CAEPs are emerging as an important tool in the objective evaluation of hearing aid and cochlear implant fittings. Responses to closely spaced stimuli provide objective information about integration and inhibition mechanisms in the auditory cortex.
AB - Objective: The first aim of this study is to validate the theoretical framework of least-squares (LS) deconvolution on experimental data. The second is to investigate the waveform morphology of the cortical auditory evoked potential (CAEP) for five stimulus onset-asynchronies (SOAs) and effects of alternating stimulus frequency in normally hearing adults. Methods: Eleven adults (19-55. years) with normal hearing were investigated using tone-burst stimuli of 500 and 2000. Hz with SOAs jittered around 150, 250, 450, and 850. ms in a paired-interval paradigm with fixed or alternating stimulus frequency. Results: The LS deconvolution technique disentangled the overlapping responses, which then provided the following insights. The CAEP amplitude reached a minimum value for SOAs jittered around 450. ms, in contrast with significantly larger amplitudes for SOAs jittered around 150 and 850. ms. Despite this, longer latencies of N1 and P2 consistently occurred for decreasing SOAs. Alternating stimulus frequency significantly increased the amplitude of the CAEP response and decreased latencies for SOAs jittered around 150. ms. Effects of SOAs and alternating stimuli on CAEP amplitude can be modelled using a quantitative model of latent inhibition. Conclusions: LS deconvolution allows correction for cortical response overlap. The amplitude of the CAEP is sensitive to SOA and stimulus frequency alternation. Significance: CAEPs are emerging as an important tool in the objective evaluation of hearing aid and cochlear implant fittings. Responses to closely spaced stimuli provide objective information about integration and inhibition mechanisms in the auditory cortex.
KW - Alternating stimulus frequency
KW - Cortical auditory evoked potential
KW - Electroencephalography
KW - Least-squares deconvolution
KW - Stimulus onset-asynchrony
UR - http://www.scopus.com/inward/record.url?scp=84896706848&partnerID=8YFLogxK
U2 - 10.1016/j.clinph.2013.09.031
DO - 10.1016/j.clinph.2013.09.031
M3 - Article
C2 - 24269614
AN - SCOPUS:84896706848
SN - 1388-2457
VL - 125
SP - 814
EP - 826
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
IS - 4
ER -