Decreased plasma testosterone levels in Alzheimer's disease and aged controls from Australia

Osvaldo P. Almeida, Agung Riono, Roger Clarnette, Ralph N. Martins

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Thirty-two male patients with Alzheimer's disease and 23 elderly controls were assessed for the presence of hypogonadism according to the free androgen index (FAI). Twenty-two (68.7%) patients and 17 controls (73.9%) had an FAI below 32 nmol/L (p=0.676). The FAI was not influenced by the presence of an apoE &4 allele (p=0.669). Hypogonadism is highly prevalent among older male adults with and without AD. The effects of testosterone replacement therapy for the treatment and prevention of AD requires further investigation.

Original languageEnglish
Pages (from-to)15-18
Number of pages4
JournalAlzheimer's Reports
Volume3
Issue number1
Publication statusPublished - 2000
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Free androgen index
  • Hypogonadism
  • Neuropsychology
  • Testosterone
  • Testosterone replacement therapy

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