Thirty-two male patients with Alzheimer's disease and 23 elderly controls were assessed for the presence of hypogonadism according to the free androgen index (FAI). Twenty-two (68.7%) patients and 17 controls (73.9%) had an FAI below 32 nmol/L (p=0.676). The FAI was not influenced by the presence of an apoE &4 allele (p=0.669). Hypogonadism is highly prevalent among older male adults with and without AD. The effects of testosterone replacement therapy for the treatment and prevention of AD requires further investigation.
|Number of pages||4|
|Publication status||Published - 2000|
- Alzheimer's disease
- Free androgen index
- Testosterone replacement therapy