Decreased serum zinc is an effect of ageing and not Alzheimer's disease

Alan Rembach; Dominic J. Hare; James D. Doecke; Samantha C. Burnham; Irene Volitakis; Christopher J. Fowler; Robert A. Cherny; Catriona McLean; Rudolf Grimm; Ralph Martins; David Ames; Colin L. Masters; Ashley I. Bush; Blaine R. Roberts

doi:10.1039/c4mt00060a

Decreased serum zinc is an effect of ageing and not Alzheimer's disease

Alan Rembach, Dominic J. Hare, James D. Doecke, Samantha C. Burnham, Irene Volitakis, Christopher J. Fowler, Robert A. Cherny, Catriona McLean, Rudolf Grimm, Ralph Martins, David Ames, Colin L. Masters, Ashley I. Bush, Blaine R. Roberts^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

We examined the distribution of zinc in the periphery (erythrocytes and serum) in a large, well-characterised cohort, the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, in order to determine if there is systemic perturbation in zinc homeostasis in Alzheimer's disease (AD). We observed an age dependent decrease in serum zinc of approximately 0.4% per year. When correcting for the age dependent decline in serum zinc no significant difference between healthy controls (HC), mildly cognitively impaired (MCI) or AD subjects was observed.

Original language	English
Pages (from-to)	1216-1219
Number of pages	4
Journal	Metallomics
Volume	6
Issue number	7
DOIs	https://doi.org/10.1039/c4mt00060a
Publication status	Published - Jul 2014
Externally published	Yes

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title = "Decreased serum zinc is an effect of ageing and not Alzheimer's disease",

abstract = "We examined the distribution of zinc in the periphery (erythrocytes and serum) in a large, well-characterised cohort, the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, in order to determine if there is systemic perturbation in zinc homeostasis in Alzheimer's disease (AD). We observed an age dependent decrease in serum zinc of approximately 0.4% per year. When correcting for the age dependent decline in serum zinc no significant difference between healthy controls (HC), mildly cognitively impaired (MCI) or AD subjects was observed.",

author = "Alan Rembach and Hare, {Dominic J.} and Doecke, {James D.} and Burnham, {Samantha C.} and Irene Volitakis and Fowler, {Christopher J.} and Cherny, {Robert A.} and Catriona McLean and Rudolf Grimm and Ralph Martins and David Ames and Masters, {Colin L.} and Bush, {Ashley I.} and Roberts, {Blaine R.}",

year = "2014",

month = jul,

doi = "10.1039/c4mt00060a",

language = "English",

volume = "6",

pages = "1216--1219",

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T1 - Decreased serum zinc is an effect of ageing and not Alzheimer's disease

AU - Rembach, Alan

AU - Hare, Dominic J.

AU - Doecke, James D.

AU - Burnham, Samantha C.

AU - Volitakis, Irene

AU - Fowler, Christopher J.

AU - Cherny, Robert A.

AU - McLean, Catriona

AU - Grimm, Rudolf

AU - Martins, Ralph

AU - Ames, David

AU - Masters, Colin L.

AU - Bush, Ashley I.

AU - Roberts, Blaine R.

PY - 2014/7

Y1 - 2014/7

N2 - We examined the distribution of zinc in the periphery (erythrocytes and serum) in a large, well-characterised cohort, the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, in order to determine if there is systemic perturbation in zinc homeostasis in Alzheimer's disease (AD). We observed an age dependent decrease in serum zinc of approximately 0.4% per year. When correcting for the age dependent decline in serum zinc no significant difference between healthy controls (HC), mildly cognitively impaired (MCI) or AD subjects was observed.

AB - We examined the distribution of zinc in the periphery (erythrocytes and serum) in a large, well-characterised cohort, the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, in order to determine if there is systemic perturbation in zinc homeostasis in Alzheimer's disease (AD). We observed an age dependent decrease in serum zinc of approximately 0.4% per year. When correcting for the age dependent decline in serum zinc no significant difference between healthy controls (HC), mildly cognitively impaired (MCI) or AD subjects was observed.

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SN - 1756-5901

VL - 6

SP - 1216

EP - 1219

JO - Metallomics

JF - Metallomics

IS - 7

ER -

Decreased serum zinc is an effect of ageing and not Alzheimer's disease

Abstract

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