Degradation of missense mutant β-galactosidase proteins in Escherichia coli K-12

P. L. Bergquist; Penelope Truman

doi:10.1007/BF00267605

Degradation of missense mutant β-galactosidase proteins in Escherichia coli K-12

P. L. Bergquist^*, Penelope Truman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Ten out of 43 missense mutations in the lacZ gene of Escherichia coli gave rise to polypeptide chains that were degraded in vivo. While many of the mutants appeared to be fully or partially CRM^-, there appeared to be no obvious correlation between degradation, map position, altered subunit association and the half-life of the mutant proteins.

Original language	English
Pages (from-to)	105-108
Number of pages	4
Journal	MGG Molecular & General Genetics
Volume	164
Issue number	1
DOIs	https://doi.org/10.1007/BF00267605
Publication status	Published - Jan 1978
Externally published	Yes

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title = "Degradation of missense mutant β-galactosidase proteins in Escherichia coli K-12",

abstract = "Ten out of 43 missense mutations in the lacZ gene of Escherichia coli gave rise to polypeptide chains that were degraded in vivo. While many of the mutants appeared to be fully or partially CRM-, there appeared to be no obvious correlation between degradation, map position, altered subunit association and the half-life of the mutant proteins.",

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AB - Ten out of 43 missense mutations in the lacZ gene of Escherichia coli gave rise to polypeptide chains that were degraded in vivo. While many of the mutants appeared to be fully or partially CRM-, there appeared to be no obvious correlation between degradation, map position, altered subunit association and the half-life of the mutant proteins.

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Degradation of missense mutant β-galactosidase proteins in Escherichia coli K-12

Abstract

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