Degradation of missense mutant β-galactosidase proteins in Escherichia coli K-12

P. L. Bergquist*, Penelope Truman

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Citations (Scopus)


Ten out of 43 missense mutations in the lacZ gene of Escherichia coli gave rise to polypeptide chains that were degraded in vivo. While many of the mutants appeared to be fully or partially CRM-, there appeared to be no obvious correlation between degradation, map position, altered subunit association and the half-life of the mutant proteins.

Original languageEnglish
Pages (from-to)105-108
Number of pages4
JournalMGG Molecular & General Genetics
Issue number1
Publication statusPublished - Jan 1978
Externally publishedYes


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