Delay in opening the infarct related coronary artery increases plasma atrial natriuretic peptide levels

Craig S. McLachlan; Jianlin Yin; Catherine Driussi; Adam J. Landau; Xavier Chaufour; Geoffery White; Brett Hambly; Mark A. McGuire

doi:10.1016/S0014-2999(99)00497-5

Delay in opening the infarct related coronary artery increases plasma atrial natriuretic peptide levels

Craig S. McLachlan^*, Jianlin Yin, Catherine Driussi, Adam J. Landau, Xavier Chaufour, Geoffery White, Brett Hambly, Mark A. McGuire

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Plasma atrial natriuretic peptide (ANP) levels were measured in rabbits during the late healing phase of myocardial infarcts. Significant differences in plasma ANP levels (P<0.02) were found between rabbits that had undergone very late (6 h) or early reperfusion (20 and 45 min of ischemia) of the infarct related coronary artery. Differences in ANP levels were independent of infarct size, ventricular remodeling and infarct expansion. We conclude late reperfusion of infarct related artery, independent of myocardial salvage, is associated with increased circulating ANP plasma levels.

Original language	English
Journal	European Journal of Pharmacology
Volume	379
Issue number	1
DOIs	https://doi.org/10.1016/S0014-2999(99)00497-5
Publication status	Published - 20 Aug 1999

Keywords

ANP atrial natriuretic peptide
Myocardial infarction
Reperfusion, late

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10.1016/S0014-2999(99)00497-5

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title = "Delay in opening the infarct related coronary artery increases plasma atrial natriuretic peptide levels",

abstract = "Plasma atrial natriuretic peptide (ANP) levels were measured in rabbits during the late healing phase of myocardial infarcts. Significant differences in plasma ANP levels (P<0.02) were found between rabbits that had undergone very late (6 h) or early reperfusion (20 and 45 min of ischemia) of the infarct related coronary artery. Differences in ANP levels were independent of infarct size, ventricular remodeling and infarct expansion. We conclude late reperfusion of infarct related artery, independent of myocardial salvage, is associated with increased circulating ANP plasma levels.",

keywords = "ANP atrial natriuretic peptide, Myocardial infarction, Reperfusion, late",

author = "McLachlan, {Craig S.} and Jianlin Yin and Catherine Driussi and Landau, {Adam J.} and Xavier Chaufour and Geoffery White and Brett Hambly and McGuire, {Mark A.}",

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T1 - Delay in opening the infarct related coronary artery increases plasma atrial natriuretic peptide levels

AU - McLachlan, Craig S.

AU - Yin, Jianlin

AU - Driussi, Catherine

AU - Landau, Adam J.

AU - Chaufour, Xavier

AU - White, Geoffery

AU - Hambly, Brett

AU - McGuire, Mark A.

PY - 1999/8/20

Y1 - 1999/8/20

N2 - Plasma atrial natriuretic peptide (ANP) levels were measured in rabbits during the late healing phase of myocardial infarcts. Significant differences in plasma ANP levels (P<0.02) were found between rabbits that had undergone very late (6 h) or early reperfusion (20 and 45 min of ischemia) of the infarct related coronary artery. Differences in ANP levels were independent of infarct size, ventricular remodeling and infarct expansion. We conclude late reperfusion of infarct related artery, independent of myocardial salvage, is associated with increased circulating ANP plasma levels.

AB - Plasma atrial natriuretic peptide (ANP) levels were measured in rabbits during the late healing phase of myocardial infarcts. Significant differences in plasma ANP levels (P<0.02) were found between rabbits that had undergone very late (6 h) or early reperfusion (20 and 45 min of ischemia) of the infarct related coronary artery. Differences in ANP levels were independent of infarct size, ventricular remodeling and infarct expansion. We conclude late reperfusion of infarct related artery, independent of myocardial salvage, is associated with increased circulating ANP plasma levels.

KW - ANP atrial natriuretic peptide

KW - Myocardial infarction

KW - Reperfusion, late

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DO - 10.1016/S0014-2999(99)00497-5

M3 - Article

C2 - 10499381

AN - SCOPUS:0032694631

SN - 0014-2999

VL - 379

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1

ER -

Delay in opening the infarct related coronary artery increases plasma atrial natriuretic peptide levels

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