Delineation of modular proteins

domain boundary prediction from sequence information.

Lesheng Kong*, Shoba Ranganathan

*Corresponding author for this work

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The delineation of domain boundaries of a given sequence in the absence of known 3D structures or detectable sequence homology to known domains benefits many areas in protein science, such as protein engineering, protein 3D structure determination and protein structure prediction. With the exponential growth of newly determined sequences, our ability to predict domain boundaries rapidly and accurately from sequence information alone is both essential and critical from the viewpoint of gene function annotation. Anyone attempting to predict domain boundaries for a single protein sequence is invariably confronted with a plethora of databases that contain boundary information available from the internet and a variety of methods for domain boundary prediction. How are these derived and how well do they work? What definition of 'domain' do they use? We will first clarify the different definitions of protein domains, and then describe the available public databases with domain boundary information. Finally, we will review existing domain boundary prediction methods and discuss their strengths and weaknesses.

Original languageEnglish
Pages (from-to)179-192
Number of pages14
JournalBriefings in Bioinformatics
Volume5
Issue number2
DOIs
Publication statusPublished - Jun 2004

Fingerprint Dive into the research topics of 'Delineation of modular proteins: domain boundary prediction from sequence information.'. Together they form a unique fingerprint.

  • Cite this