Descending pain modulation in irritable bowel syndrome (IBS): a systematic review and meta-analysis

Rosemary J. Chakiath*, Philip J. Siddall, John E. Kellow, Julia M. Hush, Mike P. Jones, Anna Marcuzzi, Paul J. Wrigley

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)
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Background: Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. While abdominal pain is a dominant symptom of IBS, many sufferers also report widespread hypersensitivity and present with other chronic pain conditions. The presence of widespread hypersensitivity and extra-intestinal pain conditions suggests central nervous dysfunction. While central nervous system dysfunction may involve the spinal cord (central sensitisation) and brain, this review will focus on one brain mechanism, descending pain modulation. Method/design: We will conduct a comprehensive search for the articles indexed in the databases Ovid MEDLINE, Ovid Embase, Ovid PsycINFO and Cochrane Central Register of Controlled Trial (CENTRAL) from their inception to August 2015, that report on any aspect of descending pain modulation in irritable bowel syndrome. Two independent reviewers will screen studies for eligibility, assess risk of bias and extract relevant data. Results will be tabulated and, if possible, a meta-analysis will be carried out. Discussion: The systematic review outlined in this protocol aims to summarise current knowledge regarding descending pain modulation in IBS. Systematic review registration: PROSPERO CRD42015024284

Original languageEnglish
Article number175
Pages (from-to)1-6
Number of pages6
JournalSystematic Reviews
Publication statusPublished - 10 Dec 2015

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Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.


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