Descending pain modulation in irritable bowel syndrome (IBS): a systematic review and meta-analysis

Rosemary J. Chakiath; Philip J. Siddall; John E. Kellow; Julia M. Hush; Mike P. Jones; Anna Marcuzzi; Paul J. Wrigley

doi:10.1186/s13643-015-0162-8

Descending pain modulation in irritable bowel syndrome (IBS): a systematic review and meta-analysis

Rosemary J. Chakiath^*, Philip J. Siddall, John E. Kellow, Julia M. Hush, Mike P. Jones, Anna Marcuzzi, Paul J. Wrigley

^*Corresponding author for this work

Faculty of Medicine, Health and Human Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. While abdominal pain is a dominant symptom of IBS, many sufferers also report widespread hypersensitivity and present with other chronic pain conditions. The presence of widespread hypersensitivity and extra-intestinal pain conditions suggests central nervous dysfunction. While central nervous system dysfunction may involve the spinal cord (central sensitisation) and brain, this review will focus on one brain mechanism, descending pain modulation. Method/design: We will conduct a comprehensive search for the articles indexed in the databases Ovid MEDLINE, Ovid Embase, Ovid PsycINFO and Cochrane Central Register of Controlled Trial (CENTRAL) from their inception to August 2015, that report on any aspect of descending pain modulation in irritable bowel syndrome. Two independent reviewers will screen studies for eligibility, assess risk of bias and extract relevant data. Results will be tabulated and, if possible, a meta-analysis will be carried out. Discussion: The systematic review outlined in this protocol aims to summarise current knowledge regarding descending pain modulation in IBS. Systematic review registration: PROSPERO CRD42015024284

Original language	English
Article number	175
Pages (from-to)	1-6
Number of pages	6
Journal	Systematic Reviews
Volume	4
DOIs	https://doi.org/10.1186/s13643-015-0162-8
Publication status	Published - 10 Dec 2015

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Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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title = "Descending pain modulation in irritable bowel syndrome (IBS): a systematic review and meta-analysis",

abstract = "Background: Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. While abdominal pain is a dominant symptom of IBS, many sufferers also report widespread hypersensitivity and present with other chronic pain conditions. The presence of widespread hypersensitivity and extra-intestinal pain conditions suggests central nervous dysfunction. While central nervous system dysfunction may involve the spinal cord (central sensitisation) and brain, this review will focus on one brain mechanism, descending pain modulation. Method/design: We will conduct a comprehensive search for the articles indexed in the databases Ovid MEDLINE, Ovid Embase, Ovid PsycINFO and Cochrane Central Register of Controlled Trial (CENTRAL) from their inception to August 2015, that report on any aspect of descending pain modulation in irritable bowel syndrome. Two independent reviewers will screen studies for eligibility, assess risk of bias and extract relevant data. Results will be tabulated and, if possible, a meta-analysis will be carried out. Discussion: The systematic review outlined in this protocol aims to summarise current knowledge regarding descending pain modulation in IBS. Systematic review registration: PROSPERO CRD42015024284",

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AU - Siddall, Philip J.

AU - Kellow, John E.

AU - Hush, Julia M.

AU - Jones, Mike P.

AU - Marcuzzi, Anna

AU - Wrigley, Paul J.

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PY - 2015/12/10

Y1 - 2015/12/10

N2 - Background: Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. While abdominal pain is a dominant symptom of IBS, many sufferers also report widespread hypersensitivity and present with other chronic pain conditions. The presence of widespread hypersensitivity and extra-intestinal pain conditions suggests central nervous dysfunction. While central nervous system dysfunction may involve the spinal cord (central sensitisation) and brain, this review will focus on one brain mechanism, descending pain modulation. Method/design: We will conduct a comprehensive search for the articles indexed in the databases Ovid MEDLINE, Ovid Embase, Ovid PsycINFO and Cochrane Central Register of Controlled Trial (CENTRAL) from their inception to August 2015, that report on any aspect of descending pain modulation in irritable bowel syndrome. Two independent reviewers will screen studies for eligibility, assess risk of bias and extract relevant data. Results will be tabulated and, if possible, a meta-analysis will be carried out. Discussion: The systematic review outlined in this protocol aims to summarise current knowledge regarding descending pain modulation in IBS. Systematic review registration: PROSPERO CRD42015024284

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Descending pain modulation in irritable bowel syndrome (IBS): a systematic review and meta-analysis

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