Design and rationale of the COVID-19 Critical Care Consortium international, multicentre, observational study

Gianluigi Li Bassi*, Jacky Suen, Adrian Gerard Barnett, Amanda Corley, Jonathan Millar, Jonathon Fanning, India Lye, Sebastiano Colombo, Karin Wildi, Samantha Livingstone, Gabriella Abbate, Samuel Hinton, Benoit Liquet, Sally Shrapnel, Heidi Dalton, John F. Fraser, COVID-19 Critical Care Consortium

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Introduction: There is a paucity of data that can be used to guide the management of critically ill patients with COVID-19. In response, a research and data-sharing collaborative-The COVID-19 Critical Care Consortium-has been assembled to harness the cumulative experience of intensive care units (ICUs) worldwide. The resulting observational study provides a platform to rapidly disseminate detailed data and insights crucial to improving outcomes.

Methods and analysis: This is an international, multicentre, observational study of patients with confirmed or suspected SARS-CoV-2 infection admitted to ICUs. This is an evolving, open-ended study that commenced on 1 January 2020 and currently includes >350 sites in over 48 countries. The study enrols patients at the time of ICU admission and follows them to the time of death, hospital discharge or 28 days post-ICU admission, whichever occurs last. Key data, collected via an electronic case report form devised in collaboration with the International Severe Acute Respiratory and Emerging Infection Consortium/Short Period Incidence Study of Severe Acute Respiratory Illness networks, include: patient demographic data and risk factors, clinical features, severity of illness and respiratory failure, need for non-invasive and/or mechanical ventilation and/or extracorporeal membrane oxygenation and associated complications, as well as data on adjunctive therapies.

Ethics and dissemination: Local principal investigators will ensure that the study adheres to all relevant national regulations, and that the necessary approvals are in place before a site may contribute data. In jurisdictions where a waiver of consent is deemed insufficient, prospective, representative or retrospective consent will be obtained, as appropriate. A web-based dashboard has been developed to provide relevant data and descriptive statistics to international collaborators in real-time. It is anticipated that, following study completion, all de-identified data will be made open access.

Trial registration number: ACTRN12620000421932 (http://anzctr.org.au/ACTRN12620000421932.aspx).

Original languageEnglish
Article numbere041417
Pages (from-to)1-6
Number of pages6
JournalBMJ Open
Volume10
Issue number12
DOIs
Publication statusPublished - 2 Dec 2020
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • epidemiology
  • intensive & critical care
  • public health
  • respiratory infections

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