TY - JOUR
T1 - Design and synthesis of a ruthenium(II) complex-based luminescent probe for highly selective and sensitive luminescence detection of nitric oxide
AU - Yu, Xiaojing
AU - Zhang, Run
AU - Ye, Zhiqiang
AU - Song, Bo
AU - Yuan, Jingli
PY - 2013/11
Y1 - 2013/11
N2 - Nitric oxide (NO) is one of the most important intercellular signaling molecules, and plays important roles in various biological systems. In this work, a unique RuII complex, tris[(5-(4-methylamino-3- aminobenzylamino)-1,10-phenanthroline)] ruthenium(II) hexafluorophosphate [Ru(MAA-phen)3][PF6]2, has been designed and synthesized as a luminescent probe for the detection of NO in aqueous media. The complex itself is almost non-luminescent, but can specifically react with NO under the aerobic conditions to afford its highly luminescent triazole derivative in aqueous media, [Ru(MTA-phen)3]2+ (MTA-phen: methyl-trazolebenzylamino-1,10-phenanthroline), accompanied by a 302-fold increase in luminescence intensity at 598 nm with a 130 nm Stokes shift. The luminescence response of [Ru(MAA-phen)3]2+ to NO is rapid, highly specific without interferences of other reactive oxygen/nitrogen species, and highly stable against the pH changes in the range of pH 4.5-9.5. These features enable [Ru(MAA-phen)3]2+ to be used as a probe for the highly selective and sensitive luminescence detection of NO in weakly acidic, neutral, and weakly basic media.
AB - Nitric oxide (NO) is one of the most important intercellular signaling molecules, and plays important roles in various biological systems. In this work, a unique RuII complex, tris[(5-(4-methylamino-3- aminobenzylamino)-1,10-phenanthroline)] ruthenium(II) hexafluorophosphate [Ru(MAA-phen)3][PF6]2, has been designed and synthesized as a luminescent probe for the detection of NO in aqueous media. The complex itself is almost non-luminescent, but can specifically react with NO under the aerobic conditions to afford its highly luminescent triazole derivative in aqueous media, [Ru(MTA-phen)3]2+ (MTA-phen: methyl-trazolebenzylamino-1,10-phenanthroline), accompanied by a 302-fold increase in luminescence intensity at 598 nm with a 130 nm Stokes shift. The luminescence response of [Ru(MAA-phen)3]2+ to NO is rapid, highly specific without interferences of other reactive oxygen/nitrogen species, and highly stable against the pH changes in the range of pH 4.5-9.5. These features enable [Ru(MAA-phen)3]2+ to be used as a probe for the highly selective and sensitive luminescence detection of NO in weakly acidic, neutral, and weakly basic media.
KW - Luminescence detection
KW - Luminescent probe
KW - Nitric oxide
KW - Ruthenium complex
UR - http://www.scopus.com/inward/record.url?scp=84886791552&partnerID=8YFLogxK
U2 - 10.1007/s10895-013-1240-8
DO - 10.1007/s10895-013-1240-8
M3 - Article
C2 - 23728714
AN - SCOPUS:84886791552
VL - 23
SP - 1113
EP - 1120
JO - Journal of Fluorescence
JF - Journal of Fluorescence
SN - 1053-0509
IS - 6
ER -