A gold standard for the validation of diffusion weighted magnetic resonance imaging (DW-MRI) in brain white matter (WM) is essential for clinical purposes but still not available. Synthetic anisotropic fiber bundles are proposed as phantoms for the validation of DW-MRI because of their well-known structure, their long preservability and the possibility to create complex geometries such as curved and fiber crossings. A crucial question is how the different material properties and size of the fiber phantoms influence the outcome of the DW-MRI experiment. Several fiber materials are compared in this study. The effect of surface relaxation and internal gradients on the SNR is evaluated. In addition, the dependency of the fiber density and fiber radius on the diffusion properties is investigated.
|Number of pages||3|
|Journal||Magnetic Resonance in Porous Media : A selection of papers presented at the 9th International Bologna Conference Magnetic Resonance in Porous Media (MRPM 9), July 2008, Cambridge MA, USA|
|Publication status||Published - 2009|
|Event||International Bologna Conference Magnetic Resonance in Porous Media (9th : 2008) - Cambridge MA|
Duration: 13 Jul 2008 → 17 Jul 2008