Design of high power LED-based UVA emission system and a photosensitive substance for clinical application in corneal radiation

Alessandro D. Mota*, André M. Cestari, André O. De Oliveira, Anselmo G. Oliveira, Cristina H. B. Terruggi, Giuliano Rossi, Jarbas C. Castro, João P. B. Ligabô, Tiago A. Ortega, Tiago Rosa

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

Abstract

This work presents an innovative cross-linking procedure to keratoconus treatment, a corneal disease. It includes the development of an ultraviolet controlled emission portable device based on LED source and a new formulation of a photosensitive drug called riboflavin. Thus new formulation improves drug administration by its transepithelial property. The UV reaction with riboflavin in corneal tissue leads to a modification of corneal collagen fibers, turning them more rigid and dense, and consequently restraining the advance of the disease. We present the control procedures to maintain UV output power stable up to 45mw/cm2, the optical architecture that leads to a homogeneous UV spot and the new formulation of Riboflavin.

Original languageEnglish
Title of host publicationFourteenth International Conference on Solid State Lighting and LED-Based Illumination Systems
EditorsMatthew H. Kane, Jianzhong Jiao, Nikolaus Dietz, Jian-Jang Huang
Place of PublicationBellingham, WA
PublisherSPIE
Pages95710X-1-95710X-13
Number of pages13
ISBN (Electronic)9781628417371
DOIs
Publication statusPublished - 2015
Externally publishedYes
Event14th International Conference on Solid State Lighting and LED-Based Illumination Systems - San Diego, United States
Duration: 12 Aug 201513 Aug 2015

Publication series

NameProceedings of SPIE
PublisherSPIE
Volume9571
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Other

Other14th International Conference on Solid State Lighting and LED-Based Illumination Systems
CountryUnited States
CitySan Diego
Period12/08/1513/08/15

Keywords

  • Ultraviolet LED
  • Cross-linking
  • Keratoconus
  • Riboflavin
  • Transepithelial
  • PID control system for LEDs
  • Close loop system for LED
  • UV based Optical system

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