Design, synthesis, and characterisation of glyoxylamide-based short peptides as self-assembled gels

Vina R. Aldilla, Shashidhar Nizalapur, Adam Martin, Chris E. Marjo, Anne Rich, Eugene Yee, Panthipa Suwannakot, David StC. Black, Pall Thordarson, Naresh Kumar

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The synthesis and supramolecular properties of novel glyoxylamide-based short peptides formed via the ring-opening reaction of N-acetylisatins in solution phase are described. The short peptides self-assembled into gels, which were examined for their mechanical and morphological characteristics using multiple spectroscopic and microscopy techniques. The critical gel concentration and mechanical strength of the self-assembled gels were influenced by the presence of electronegative substituents (such as fluoro, in 5b) or hydrophobic substituents (such as bromo, 5d) respectively in the short peptides. Moreover, in vitro cytotoxicity assays demonstrated that these compounds were non-toxic to mammalian cells.
Original languageEnglish
Pages (from-to)13462-13471
Number of pages10
JournalNew Journal of Chemistry
Volume41
Issue number22
DOIs
Publication statusPublished - 2017
Externally publishedYes

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